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Urate and risk of Alzheimer's disease and vascular dementia: A population-based study


Scheepers, LEJM and Jacobsson, LTH and Kern, S and Johansson, L and Dehlin, M and Skoog, I, Urate and risk of Alzheimer's disease and vascular dementia: A population-based study, Alzheimer's & Dementia, 15, (6) pp. 754-763. ISSN 1552-5260 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 the Alzheimer’s Association

DOI: doi:10.1016/j.jalz.2019.01.014


Introduction: Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity. On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia.

Methods: In 1968–1969, a population-based sample of 1462 women aged 38 to 60 years was examined and were followed up over 44 years (mean 33.1 years). We examined whether sU (determined in 1968–1969 and 1992–1994) is associated with risk of late-life dementia.

Results: During 44 years of follow-up, a higher sU (per standard deviation of 76.5 mmol/L) was associated with lower risk for dementia (n 5 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72– 0.91), Alzheimer’s disease (n 5 152; HR 0.78; CI 0.66–0.91), and vascular dementia (n 5 52; HR 0.66; CI 0.47–0.94).

Discussion: Our findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout.

Item Details

Item Type:Refereed Article
Keywords:dementia, alzheimer's, vascular dementia, urate, uric acid, gout
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Determinants of health
UTAS Author:Scheepers, LEJM (Dr Lieke Scheepers)
ID Code:142404
Year Published:2019
Web of Science® Times Cited:33
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-01-14
Last Modified:2022-08-23

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