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Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study


Scheepers, LEJM and Boonen, A and Pijnenburg, W and Bierau, J and Staessen, JA and Stehouwer, CDA and Thijs, C and Arts, ICW, Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study, Journal of Hypertension, 35, (5) pp. 982-993. ISSN 0263-6352 (2017) [Refereed Article]

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Copyright 2019 the Alzheimerís Association. Published by Elsevier Inc.

DOI: doi:10.1097/HJH.0000000000001270


Objective: Elevated serum uric acid concentration has been associated with high blood pressure (BP) and hypertension. A putative underlying mechanism is the accumulation of reactive oxygen species when uric acid is generated by an increased enzyme activity of xanthine oxidase (XO). The aims of the present study were to investigate the associations between plasma uric acid concentration, purine metabolite ratios, as proxies for increased XO activity, and SBP and DBP in school-age children.

Methods: Cross-sectional analyses were performed in 246 children (46% boys; mean age 7.1 years) from the Dutch KOALA Birth Cohort Study. Purine metabolites were determined with ultra-performance liquid chromatography-tandem mass spectrometry. During a home visit, a nurse collected a blood sample and measured BP three times; in addition, parents measured their child's BP on three consecutive days, in the morning and evening. Generalized estimating equations were used for analyses while controlling for variables such as sex, age, BMI, physical activity, and dietary intake.

Results: In multivariable analysis, uric acid (per SD of 38 μmol/l) was associated with DBP z-scores [sβ 0.07; confidence interval (CI), 0.01-1.14], but not with SBP z-scores. Higher ratios of uric acid/xanthine (per SD of 138) (sβ 0.09; CI, 0.01-0.17) and xanthine/hypoxanthine (per SD of 321) (sβ 0.08; CI, 0.02-0.17) were associated with higher DBP z-scores, but not with SBP z-scores.

Conclusion: In school-age children, uric acid and the ratios of uric acid/xanthine and xanthine/hypoxanthine were significantly associated with DBP z-scores. Suggesting that, both uric acid concentration and increased XO activity are associated with BP.

Item Details

Item Type:Refereed Article
Keywords:uric acid, urate, blood pressure, child, birth-cohort, epidemiology
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Determinants of health
UTAS Author:Scheepers, LEJM (Dr Lieke Scheepers)
ID Code:142401
Year Published:2017
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-01-14
Last Modified:2022-08-25

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