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Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study

Citation

Scheepers, LEJM and Boonen, A and Dagnelie, PC and Schram, MT and van der Kallen, CJH and Henry, RMA and Kroon, AA and Stehouwer, CDA and Arts, ICW, Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study, Journal of Hypertension, 35, (10) pp. 1968-1975. ISSN 0263-6352 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Wolters Kluwer Health

DOI: doi:10.1097/HJH.0000000000001417

Abstract

Objective: Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension.

Methods: Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension.

Results: After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated with higher 24-h MAP [β 0.63 mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140 mg/day/1.73 m) was associated with higher 24-h MAP (β 0.79 mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no significant association between serum and 24-h urinary uric acid excretion with 24-h pulse pressure. There was no interaction with sex or age for the aforementioned associations.

Conclusion: Higher serum and urinary uric acid concentrations were associated with higher 24-h MAP and hypertension. These results suggest that serum and 24-urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension.

Item Details

Item Type:Refereed Article
Keywords:urate, uric acid, blood pressure, hypertension, epidemiology. metabolite
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Scheepers, LEJM (Dr Lieke Scheepers)
ID Code:142400
Year Published:2017
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-01-14
Last Modified:2021-03-23
Downloads:0

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