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Adjunctive intra-operative local anaesthesia in paediatric strabismus surgery: A randomized controlled trial


Carden, SM and Colville, DJ and Davidson, AJ and McKenzie, IM and Mackey, DA and McKenzie, J and Elder, JE, Adjunctive intra-operative local anaesthesia in paediatric strabismus surgery: A randomized controlled trial, Australian and New Zealand Journal of Ophthalmology, 26, (4) pp. 289-297. ISSN 0814-9763 (1998) [Refereed Article]

DOI: doi:10.1111/j.1442-9071.1998.tb01332.x


Purpose: The aim of the present study was to test the hypothesis that adjunctive local anaesthesia decreases postoperative pain, vomiting or length of stay in children having strabismus repair. Method: A prospective, randomized, triple-armed clinical trial involving a treatment comparison between topical amethocaine, sub-conjunctival bupivacaine and, as a placebo, topical normal saline was performed. All treatments were given at the end of surgery before emergence from the anaesthetic. Results: Overall, there was no statistically significant difference between outcome measures in the three trial groups. Using post hoc analysis there was a statistically significant difference between the groups receiving amethocaine and bupivacaine compared with the saline group in terms of the pain score at 120 min postoperatively. This difference has little clinical significance. Conclusions: Neither topical amethocaine nor subconjunctival bupivacaine makes a clinically significant difference to postoperative pain, emesis or length of stay. Moderate dose paracetamol per rectum alone appears to be effective analgesia for strabismus surgery, although it probably masked any small adjunctive effect of the topical anaesthesia used in the present trial.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Anaesthesiology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Mackey, DA (Professor David Mackey)
ID Code:14238
Year Published:1998
Web of Science® Times Cited:12
Deposited By:Menzies Centre
Deposited On:1998-08-01
Last Modified:2011-08-09

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