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Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil (Sarcophilus harrisii) populations


Fraik, AK and Margres, MJ and Epstein, B and Barbosa, S and Jones, M and Hendricks, S and Schonfeld, B and Stahlke, AR and Veillet, A and Hamede, R and McCallum, H and Lopez-Contreras, E and Kallinen, SJ and Hohenlohe, PA and Kelley, JL and Storfer, A, Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil (Sarcophilus harrisii) populations, Evolution, 74, (7) pp. 1392-1408. ISSN 0014-3820 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 the authors

DOI: doi:10.1111/evo.14023


Landscape genomics studies focus on identifying candidate genes under selection via spatial variation in abiotic environmental variables, but rarely by biotic factors (i.e., disease). The Tasmanian devil (Sarcophilus harrisii) is found only on the environmentally heterogeneous island of Tasmania and is threatened with extinction by a transmissible cancer, devil facial tumor disease (DFTD). Devils persist in regions of long‐term infection despite epidemiological model predictions of speciesí extinction, suggesting possible adaptation to DFTD. Here, we test the extent to which spatial variation and genetic diversity are associated with the abiotic environment (i.e., climatic variables, elevation, vegetation cover) and/or DFTD. We employ genetic‐environment association analyses using 6886 SNPs from 3287 individuals sampled pre‐ and post‐disease arrival across the devil's geographic range. Pre‐disease, we find significant correlations of allele frequencies with environmental variables, including 365 unique loci linked to 71 genes, suggesting local adaptation to abiotic environment. The majority of candidate loci detected pre‐DFTD are not detected post‐DFTD arrival. Several post‐DFTD candidate loci are associated with disease prevalence and were in linkage disequilibrium with genes involved in tumor suppression and immune response.†Loss of apparent signal of abiotic local adaptation post‐disease suggests swamping by strong selection resulting from the rapid onset of DFTD.

Item Details

Item Type:Refereed Article
Keywords:Tasmanian devil, disease, adaptation, population genetics
Research Division:Biological Sciences
Research Group:Ecology
Research Field:Terrestrial ecology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Control of pests, diseases and exotic species in terrestrial environments
UTAS Author:Jones, M (Professor Menna Jones)
UTAS Author:Schonfeld, B (Dr Barbara Schonfeld)
UTAS Author:Hamede, R (Dr Rodrigo Hamede Ross)
ID Code:142315
Year Published:2020
Web of Science® Times Cited:7
Deposited By:Zoology
Deposited On:2021-01-07
Last Modified:2021-06-23

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