The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress). Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number of clinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and to disseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survival mediators and are involved in promoting cancer progression via mechanisms such as epithelial to mesenchymal transition (EMT). However, there are a few proteins among these groups which impede deleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway. The present review exposes and discusses such critical mechanisms and some of the key processes involved in carcinogenesis.

Item Type:	Refereed Article
Keywords:	ER stress, lung, GPCR, COPD, epithelium, fibrosis, EMT, Cancer, ICS, inflammation
Research Division:	Biomedical and Clinical Sciences
Research Group:	Cardiovascular medicine and haematology
Research Field:	Cardiology (incl. cardiovascular diseases)
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Diagnosis of human diseases and conditions
UTAS Author:	Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:	Lu, W (Dr Monica LU)
UTAS Author:	Azimi, I (Dr Iman Azimi)
UTAS Author:	Eri, R (Associate Professor Raj Eri)
UTAS Author:	Sohal, SS (Dr Sukhwinder Sohal)
ID Code:	142277
Year Published:	2020
Web of Science® Times Cited:	1
Deposited By:	Health Sciences
Deposited On:	2021-01-05
Last Modified:	2021-02-12
Downloads:	0