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Endogenous anti-cancer candidates in GPCR, ER stress, and EMT


Gundamaraju, R and Lu, W and Azimi, I and Eri, R and Sohal, SS, Endogenous anti-cancer candidates in GPCR, ER stress, and EMT, Biomedicines, 8, (10) pp. 1-13. ISSN 2227-9059 (2020) [Refereed Article]

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DOI: doi:10.3390/biomedicines8100402


The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress). Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number of clinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and to disseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survival mediators and are involved in promoting cancer progression via mechanisms such as epithelial to mesenchymal transition (EMT). However, there are a few proteins among these groups which impede deleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway. The present review exposes and discusses such critical mechanisms and some of the key processes involved in carcinogenesis.

Item Details

Item Type:Refereed Article
Keywords:ER stress, lung, GPCR, COPD, epithelium, fibrosis, EMT, Cancer, ICS, inflammation
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:Lu, W (Dr Monica LU)
UTAS Author:Azimi, I (Dr Iman Azimi)
UTAS Author:Eri, R (Associate Professor Raj Eri)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:142277
Year Published:2020
Web of Science® Times Cited:1
Deposited By:Health Sciences
Deposited On:2021-01-05
Last Modified:2021-02-12

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