eCite Digital Repository
Endogenous anti-cancer candidates in GPCR, ER stress, and EMT
Citation
Gundamaraju, R and Lu, W and Azimi, I and Eri, R and Sohal, SS, Endogenous anti-cancer candidates in GPCR, ER stress, and EMT, Biomedicines, 8, (10) pp. 1-13. ISSN 2227-9059 (2020) [Refereed Article]
Copyright Statement
Copyright unknown
DOI: doi:10.3390/biomedicines8100402
Abstract
The majority of cellular responses to external stimuli are mediated by receptors such as G
protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).
Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number of
clinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and to
disseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survival
mediators and are involved in promoting cancer progression via mechanisms such as epithelial to
mesenchymal transition (EMT). However, there are a few proteins among these groups which impede
deleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway.
The present review exposes and discusses such critical mechanisms and some of the key processes
involved in carcinogenesis.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | ER stress, lung, GPCR, COPD, epithelium, fibrosis, EMT, Cancer, ICS, inflammation |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Diagnosis of human diseases and conditions |
UTAS Author: | Gundamaraju, R (Mr Rohit Gundamaraju) |
UTAS Author: | Lu, W (Dr Monica Lu) |
UTAS Author: | Azimi, I (Dr Iman Azimi) |
UTAS Author: | Eri, R (Associate Professor Raj Eri) |
UTAS Author: | Sohal, SS (Dr Sukhwinder Sohal) |
ID Code: | 142277 |
Year Published: | 2020 |
Deposited By: | Health Sciences |
Deposited On: | 2021-01-05 |
Last Modified: | 2021-02-12 |
Downloads: | 0 |
Repository Staff Only: item control page