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Reperfusion Strategy and Infarct Size in ST-Elevation Myocardial Infarction (STEMI)


Said, C and Bland, A and Casinader, S and Parkinson, M and Bamford, P and Coote, E and Colgan, J and Ford, T, Reperfusion Strategy and Infarct Size in ST-Elevation Myocardial Infarction (STEMI), Heart, Lung and Circulation, 29, (2) pp. S280. ISSN 1443-9506 (2020) [Refereed Article]

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DOI: doi:10.1016/j.hlc.2020.09.548



Thrombolysis remains an important reperfusion strategy for ST segment elevation myocardial infarction (STEMI) in many outer metropolitan and regional settings. We looked to compare myocardial infarct size (assessed by peak high sensitivity troponin) according to reperfusion strategy in STEMI.


We performed a cohort study of consecutive STEMI patients presenting to two outer-metropolitan hospitals. Peak troponin during index hospitalisation was collected over a six-year period (2014-2019) along with blinded assessment for major adverse cardiac events (MACE) at one month follow-up (a composite of all-cause mortality, myocardial infarction, unplanned revascularization and readmission for heart failure).


A total of 633 patients were included with 447 (71% undergoing thrombolysis) and the remainder undergoing primary percutaneous intervention (pPCI). Despite similar ischaemic times, myocardial necrosis was numerically greater in thrombolysed patients (median troponin =26,945ng/L IQR 78,766ng/L) v median 12,627ng/L IQR 43,646 ng/L in pPCI group) however this did not reach statistical significance. For the primary outcome (MACE) thrombolysis was associated with no higher incidence of adverse events (12% v 10%, OR: 1.27, p=0.52).


There was a higher median troponin after thrombolysis compared to pPCI suggesting a greater degree of myocardial injury, however this did not reach statistical significance. Furthermore we did not demonstrate a statistical difference in the primary MACE endpoint. Our study is hypothesis generating and further local prospective randomized comparisons are required.

Item Details

Item Type:Refereed Article
Keywords:STEMI Reperfusion
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health outcomes
UTAS Author:Colgan, J (Ms Jacqueline Colgan)
ID Code:142235
Year Published:2020
Deposited By:Nursing
Deposited On:2020-12-27
Last Modified:2021-03-02

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