University of Tasmania
Browse

File(s) under permanent embargo

Brachial-cuff excess pressure is associated with carotid intima-media thickness among Australian children: a cross-sectional population study

journal contribution
posted on 2023-05-20, 19:59 authored by Peng, X, Dean PiconeDean Picone, Martin SchultzMartin Schultz, Guoqi CaiGuoqi Cai, Wake, M, Burgner, DP, Mynard, JP, Ellul, S, Cheung, M, Juonala, M, James SharmanJames Sharman
Reservoir pressure parameters (i.e., reservoir pressure [RP] and excess pressure [XSP]) independently predict cardiovascular events in adults, but this has not been investigated in children. This study aimed to determine (1) the association of reservoir pressure parameters with carotid intima-media thickness (carotid IMT), a preclinical vascular phenotype, and (2) whether a multivariable regression model with or without reservoir pressure parameters fits better for estimating carotid IMT in children. Study participants were 11-12-year-old children (n = 1231, 50% male) from the Child Health CheckPoint study, a cross-sectional substudy of the population-based Longitudinal Study of Australian Children. RP and XSP were obtained using brachial-cuff oscillometry (SphygmoCor XCEL, AtCor, Sydney). Carotid IMT was quantified by vascular ultrasonography. XSP was associated with carotid IMT after adjusting for confounders including age, sex, BMI z-score, heart rate, pubertal stage, moderate-to-vigorous physical activity, and mean arterial pressure (β = 0.93 µm, 95% CI 0.30-1.56 for XSP peak and β = 0.04 µm, 95% CI 0.01-0.08 for XSP integral). The results of the likelihood ratio test indicated a trend that the model with XSP and the above confounders fit better than a similar model without XSP for estimating carotid IMT. Our findings indicate that brachial-cuff device-measured XSP is associated with carotid IMT independent of conventional cardiovascular risk factors, including standard BP. This implies that a clinically convenient cuff approach could provide meaningful information for the early assessment of cardiovascular risk among children.

History

Publication title

Hypertension Research

Pagination

1-9

ISSN

0916-9636

Department/School

Menzies Institute for Medical Research

Publisher

Japanese Soc Hypertension Cent Academic Soc

Place of publication

Publ Office, Osaka, 14Th Fl, Senri Life Sci Center Bldg, 4-2 Shinsenri- Higashi-Machi 1Chome, Toyonaka, Japan, 565-0082

Rights statement

Copyright 2020 The Japanese Society of Hypertension

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC