eCite Digital Repository

Streptococcus thermophilus UASt-09 upregulates goblet cell activity in colonic epithelial cells to a greater degree than other probiotic strains

Citation

Shastri, MD and Chong, WC and Vemuri, R and Martoni, CJ and Adhikari, S and Bhullar, HK and Kunde, D and Tristram, SG and Eri, RD, Streptococcus thermophilus UASt-09 upregulates goblet cell activity in colonic epithelial cells to a greater degree than other probiotic strains, Microorganisms, 8, (11) pp. 1-15. ISSN 2076-2607 (2020) [Refereed Article]

Copyright Statement

Copyright unknown

DOI: doi:10.3390/microorganisms8111758

Abstract

Probiotics have been widely used in maintaining gastrointestinal health, despite their actual mechanism remaining obscure. There are several hypotheses behind the beneficial effects of probiotics including the regulation of intestinal barrier function and improvement in immune responses in the gastrointestinal system. Multiple probiotics have been introduced in the market as effective dietary supplements in improving gastrointestinal integrity, but there are no or few studies that demonstrate their underlying mechanism. In the current study, we investigated and compared the efficacy of four probiotics (based on different bacterial species) in refining gastrointestinal health by improving mucus biosynthesis and intestinal immune response under in-vitro conditions. By analyzing the gene expression of mucus biosynthesis and intestinal immune response markers, we found that probiotic Streptococcus thermophilusUASt-09 showed promising potential in refining mucosal barrier and gastrointestinal health in human colonic epithelial cells, as compared to other commercial probiotics.

Item Details

Item Type:Refereed Article
Keywords:probiotics, Mucin-2, goblet cells, intestinal peptides, immunomodulation
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Bacteriology
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Chong, WC (Mr Wai Chong)
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Adhikari, S (Mr Santosh Adhikari)
UTAS Author:Bhullar, HK (Mrs Harinder Bhullar)
UTAS Author:Kunde, D (Dr Dale Kunde)
UTAS Author:Tristram, SG (Dr Stephen Tristram)
UTAS Author:Eri, RD (Associate Professor Raj Eri)
ID Code:142181
Year Published:2020
Deposited By:Health Sciences
Deposited On:2020-12-21
Last Modified:2021-02-12
Downloads:0

Repository Staff Only: item control page