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Smoking and COVID-19: What we know so far


Shastri, MD and Shukla, SD and Chong, WC and KC, R and Dua, K and Patel, RP and Peterson, GM and O'Toole, RF, Smoking and COVID-19: What we know so far, Respiratory Medicine Article online ahead of print. ISSN 0954-6111 (2020) [Refereed Article]

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DOI: doi:10.1016/j.rmed.2020.106237


The ongoing COVID-19 pandemic has placed a spotlight on infectious diseases and their associations with host factors and underlying conditions. New data on the Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) virus are entering the public domain at a rapid rate such that their distillation often lags behind. To minimise weak associations becoming perceived as established paradigms, it is imperative that methodologies and outputs from different studies are appropriately critiqued and compared. In this review, we examine recent data on a potential relationship between smoking and COVID-19. While the causal role of smoking has been firmly demonstrated in regard to lung cancer and chronic obstructive pulmonary disease, such associations have the benefit of decadesí worth of multi-centre epidemiological and mechanistic data. From our analysis of the available studies to date, it appears that a relationship is emerging in regard to patients with a smoking history having a higher likelihood of developing more severe symptoms of COVID-19 disease than non-smokers. Data on whether COVID-19 has a greater incidence in smokers than non-smokers is thus far, contradictory and inconclusive. There is therefore a need for some caution to be exercised until further research has been conducted in a wider range of geographical settings with sufficient numbers of patients that have been carefully phenotyped in respect of smoking status and adequate statistical control for confounding factors.

Item Details

Item Type:Refereed Article
Keywords:angiotensin-converting-enzyme (ACE)-II, Coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), smoking, therapeutic targets
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Shukla, SD (Mr Shakti Shukla)
UTAS Author:KC, R (Mr Rajendra KC)
UTAS Author:Patel, RP (Dr Rahul Patel)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:142134
Year Published:2020
Deposited By:Pharmacy
Deposited On:2020-12-15
Last Modified:2020-12-16

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