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Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators


Shastri, M and Chong, WC and Dua, K and Peterson, GM and Patel, RP and Mahmood, MQ and Tambuwala, M and Chellappan, DK and Hansbro, NG and Shukla, SD and Hansbro, PM, Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators, Inflammopharmacology, 29, (1) pp. 15-33. ISSN 0925-4692 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Springer Nature Switzerland AG

DOI: doi:10.1007/s10787-020-00770-y


Asthma is a common, heterogeneous and serious disease, its prevalence has steadily risen in most parts of the world, and the condition is often inadequately controlled in many patients. Hence, there is a major need for new therapeutic approaches. Mild-to-moderate asthma is considered a T-helper cell type-2-mediated infammatory disorder that develops due to abnormal immune responses to otherwise innocuous allergens. Prolonged exposure to allergens and persistent infammation results in myofbroblast infltration and airway remodelling with mucus hypersecretion, airway smooth muscle hypertrophy, and excess collagen deposition. The airways become hyper-responsive to provocation resulting in the characteristic wheezing and obstructed airfow experienced by patients. Extensive research has progressed the understanding of the underlying mechanisms and the development of new treatments for the management of asthma. Here, we review the basis of the disease, covering new areas such as the role of vascularisation and microRNAs, as well as associated potential therapeutic interventions utilising reports from animal and human studies. We also cover novel drug delivery strategies that are being developed to enhance therapeutic efcacy and patient compliance. Potential avenues to explore to improve the future of asthma management are highlighted.

Item Details

Item Type:Refereed Article
Keywords:asthma, molecular mechanisms, vascularisation, microRNA, novel drug candidates, targeted drug delivery
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Shastri, M (Mr Madhur Shastri)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:142133
Year Published:2020
Web of Science® Times Cited:6
Deposited By:Pharmacy
Deposited On:2020-12-15
Last Modified:2021-08-17

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