Incidence and prevalence of modifiable cardiovascular risk factors according to kidney function, gender and geography
Cuthbertson, L and Cash, E and Prentice, L and Black, A and Burgess, JR and Macintyre, K and Saunder, T and Kitsos, A and Jose, K and Raj, R and McKercher, C and Radford, J and Jose, M, Incidence and prevalence of modifiable cardiovascular risk factors according to kidney function, gender and geography, pp. 19-19. ISSN 1320-5358 (2020) [Conference Extract]
Aim: To report the incidence and prevalence of modifiable cardiovascular
disease risk factors (diabetes and hyperlipidaemia) according to kidney function, gender, and geography.
Background: Cardiovascular (CV) disease increases as kidney function
decreases. Identifying individuals or communities with a high prevalence of
modifiable vascular risk factors for cardiovascular events may allow targeted
interventions to improve longer-term health.
Methods: The CKD.TASlink study takes a state-wide approach using data
linkage of five health (public hospital admissions, emergency presentations,
ANZDATA, cancer and death registry) and two pathology (community and
hospital) datasets. The study population consists of any adult who had a creatinine test between 1/1/2004 and 31/12/2017. We defined chronic kidney
disease (CKD) as two measures of eGFR<60 mL/min/1.73 m2
, at least
3-months apart. We examined the distribution of HbA1c >6.5%, LDL
>3 mmol/L and Vitamin D < 70 nmol/L in this population and data reported
using age-standardized rate and rate ratio (RR) without 95% confidence
intervals (given whole of population approach).
Results: Of the study population (n = 460,737, 86.8% of the state’s total
population), 398,661 (86.5%) had lipids, HbA1C or vitamin D measured. We
identified 56,438 Tasmanians with CKD during the study period (agestandardized annual incidence 1%; prevalence 6.5%).
In 2017, the age-standardized prevalence per 10,000 population of HbA1C
>6.5% was 373, LDL >3 mmol/L was 1141 and Vitamin D < 70 nmol/L was
799. The prevalence of HbA1C >6.5% varied by gender (men to women rate
ratio (RR) 1.29), geography by statistical area 3 (highest to lowest, RR 1.89)
and by year (2017 to 2007, RR 1.36).
Conclusions: State-wide data linkage analysis revealed significant gender,
geographic and temporal variations in modifiable cardiovascular risk factors,
including among people with CKD.