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Cardiovascular events and death in people living with chronic kidney disease

Citation

Cuthbertson, L and Cash, E and Prentice, L and Black, A and Burgess, J and Macintyre, K and Saunder, T and Kitsos, A and Jose, K and Raj, R and McKercher, CE and Radford, J and Jose, M, Cardiovascular events and death in people living with chronic kidney disease, pp. 46-46. ISSN 1320-5358 (2020) [Conference Extract]


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Abstract

Aim:

To report the rate of vascular events and death from cardiovascular causes in people living with chronic kidney disease (CKD).

Background:

Cardiovascular (CV) disease increases as kidney function decreases. Identifying individuals or communities with a high prevalence of modifiable vascular risk factors for cardiovascular events may allow targeted interventions to improve longer-term health.

Methods:

The CKD.TASlink study takes a state-wide approach using data linkage of five health (public hospital admissions, emergency presentations, ANZDATA, cancer and death registry) and two pathology (community and hospital) datasets. The study population consists of any adult who had a creatinine test between 1/1/2004 and 31/12/2017. We defined CKD as two measures of eGFR<60 mL/min/1.73 m2 , at least 3-months apart. Major CV events (diagnosis, procedural ICD-10 code or CV-related death) were identified in the admitted patient dataset and data reported using age-standardized rate and relative risks (RR) without 95% confidence intervals (given whole of population approach).

Results:

Of the study population (n = 460,737 or 86.8% of the state’s population), 227,443 (49.4%) had at least one admission, including 41,455 with CKD. There were 187 085 CV events in 77,095 individuals, 12,634 procedures and 13,696 deaths. Compared to adults without CKD, adults with CKD were more likely have an admission (RR 1.6), a major CV event (RR 5.6), major CV procedure (RR 4.8), including percutaneous coronary intervention (RR 3.6), coronary artery bypass (RR 5.1), aortic valve surgery (RR 5.3) or pacemaker insertion (RR 11.4), and more likely to die (RR 5.9) within the study period.

Conclusions:

CV events and procedures are more common in people with CKD than without CKD. Identification and optimal management of CKD may improve long-term health outcomes.

Item Details

Item Type:Conference Extract
Keywords:chronic kidney disease, dialysis, end-stage kidney disease, cardiovascular
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Nephrology and urology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Cuthbertson, L (Dr Laura Cuthbertson)
UTAS Author:Cash, E (Dr Ellie Cash)
UTAS Author:Prentice, L (Dr Louise Prentice)
UTAS Author:Black, A (Dr Andrew Black)
UTAS Author:Burgess, J (Dr John Burgess)
UTAS Author:Macintyre, K (Dr Kate Macintyre)
UTAS Author:Saunder, T (Mr Timothy Saunder)
UTAS Author:Kitsos, A (Mr Alex Kitsos)
UTAS Author:Jose, K (Dr Kim Jose)
UTAS Author:Raj, R (Dr Rajesh Raj)
UTAS Author:McKercher, CE (Dr Charlotte McKercher)
UTAS Author:Radford, J (Associate Professor Jan Radford)
UTAS Author:Jose, M (Professor Matthew Jose)
ID Code:142058
Year Published:2020
Deposited By:Medicine
Deposited On:2020-12-10
Last Modified:2021-05-21
Downloads:0

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