Cardiovascular events and death in people living with chronic kidney disease
Cuthbertson, L and Cash, E and Prentice, L and Black, A and Burgess, J and Macintyre, K and Saunder, T and Kitsos, A and Jose, K and Raj, R and McKercher, CE and Radford, J and Jose, M, Cardiovascular events and death in people living with chronic kidney disease, pp. 46-46. ISSN 1320-5358 (2020) [Conference Extract]
Aim: To report the rate of vascular events and death from cardiovascular
causes in people living with chronic kidney disease (CKD).
Background: Cardiovascular (CV) disease increases as kidney function
decreases. Identifying individuals or communities with a high prevalence of
modifiable vascular risk factors for cardiovascular events may allow targeted
interventions to improve longer-term health.
Methods: The CKD.TASlink study takes a state-wide approach using data
linkage of five health (public hospital admissions, emergency presentations,
ANZDATA, cancer and death registry) and two pathology (community and
hospital) datasets. The study population consists of any adult who had a creatinine test between 1/1/2004 and 31/12/2017. We defined CKD as two measures of eGFR<60 mL/min/1.73 m2
, at least 3-months apart. Major CV events
(diagnosis, procedural ICD-10 code or CV-related death) were identified in
the admitted patient dataset and data reported using age-standardized rate
and relative risks (RR) without 95% confidence intervals (given whole of
Results: Of the study population (n = 460,737 or 86.8% of the state’s population), 227,443 (49.4%) had at least one admission, including 41,455 with
CKD. There were 187 085 CV events in 77,095 individuals, 12,634 procedures and 13,696 deaths.
Compared to adults without CKD, adults with CKD were more likely have an
admission (RR 1.6), a major CV event (RR 5.6), major CV procedure
(RR 4.8), including percutaneous coronary intervention (RR 3.6), coronary
artery bypass (RR 5.1), aortic valve surgery (RR 5.3) or pacemaker insertion
(RR 11.4), and more likely to die (RR 5.9) within the study period.
Conclusions: CV events and procedures are more common in people with
CKD than without CKD. Identification and optimal management of CKD
may improve long-term health outcomes.