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Identifying genetic risk factors for diabetic macular edema and the response to treatment

Citation

Gurung, RL and Fitzgerald, LM and McComish, BJ and Verma, N and Burdon, KP, Identifying genetic risk factors for diabetic macular edema and the response to treatment, Journal of Diabetes Research Article 5016916. ISSN 2314-6745 (2020) [Refereed Article]


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Copyright Statement

Copyright 2020 Rajya L. Gurung et al. This is an open access article distributed under the Creative Commons Attribution License

DOI: doi:10.1155/2020/5016916

Abstract

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both genetic and environmental factors contribute to the pathophysiology of DR and its subtypes. While numerous studies have identified several susceptibility genes for DR, few have investigated the impact of genetics on DME susceptibility. This review will focus on the current literature surrounding genetic risk factors associated with DME. We will also highlight the small number of studies investigating the genetics of response to antivascular endothelial growth factor (anti-VEGF) injection, which is used to treat DME.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Gurung, RL (Dr Rajya Gurung)
UTAS Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
UTAS Author:McComish, BJ (Dr Bennet McComish)
UTAS Author:Verma, N (Dr Nitin Verma)
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
ID Code:142033
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-12-09
Last Modified:2021-02-12
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