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Idebenone: when an antioxidant is not an antioxidant

Citation

Gueven, N and Ravishankar, P and Eri, RD and Rybalka, E, Idebenone: when an antioxidant is not an antioxidant, Redox Biology, 38 Article 101812. ISSN 2213-2317 (2021) [Refereed Article]


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Copyright 2020 the Authors

DOI: doi:10.1016/j.redox.2020.101812

Abstract

Idebenone is a well described drug that was initially developed against dementia. The current literature widely portrays this molecule as a potent antioxidant and CoQ10 analogue. While numerous papers seem to support this view, a closer look indicates that the pharmacokinetics of idebenone do not support these claims. A major discrepancy between achievable tissue levels, especially in target tissues such as the brain, and doses required to show the proposed effects, significantly questions our current understanding. This review explains how this has happened and highlights the discrepancies in the current literature. More importantly, based on some recent discoveries, a new framework is presented that can explain the mode of action of this molecule and can align formerly contradictory results. Finally, this new appreciation of the molecular activities of idebenone provides a rational approach to test idebenone in novel indications that might have not been considered previously for this drug.

Item Details

Item Type:Refereed Article
Keywords:idebenone, antioxidant, radical scavenger
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Gueven, N (Dr Nuri Guven)
UTAS Author:Ravishankar, P (Ms Pranathi Ravishankar)
UTAS Author:Eri, RD (Associate Professor Raj Eri)
ID Code:142030
Year Published:2021 (online first 2020)
Web of Science® Times Cited:1
Deposited By:Pharmacy
Deposited On:2020-12-09
Last Modified:2021-02-17
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