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Timing matters: Transcranial direct current stimulation after extinction learning impairs subsequent fear extinction retention

Citation

Ney, LJ and Vicario, CM and Nitsche, MA and Felmingham, KL, Timing matters: Transcranial direct current stimulation after extinction learning impairs subsequent fear extinction retention, Neurobiology of Learning and Memory, 177 pp. 1-8. ISSN 1074-7427 (2021) [Refereed Article]

Copyright Statement

Copyright 2021 Elsevier Inc.

DOI: doi:10.1016/j.nlm.2020.107356

Abstract

Background: Transcranial direct current stimulation (tDCS) has previously been shown to improve fear extinction learning and retention when administered prior to or during extinction learning. This study investigates whether tDCS immediately following extinction learning improves efficacy of extinction memory retention.

Methods: 30 participants completed a 2-day fear learning and extinction paradigm, where they acquired fear of a stimulus conditioned to an aversive electric shock on day 1. Extinction learning occurred on day 1, with tDCS or sham tDCS administered immediately following the learning phase. Participants returned for a second day test of extinction memory recall. Skin conductance was measured as the primary outcome.

Results/Conclusions: Participants in the tDCS group showed impaired fear extinction retention on day 2, marked by significant generalisation of fear to the safety stimulus. This contrasts with earlier studies showing improved extinction retention when stimulation occurred during encoding of extinction learning, compared to immediate consolidation as in our study. These findings may have important implications for the use of tDCS during exposure therapy for anxiety and trauma disorders.

Item Details

Item Type:Refereed Article
Keywords:fear conditioning, associative learning, transcranial direct current stimulation, tdcs
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Ney, LJ (Mr Luke Ney)
ID Code:141879
Year Published:2021
Web of Science® Times Cited:3
Deposited By:Psychology
Deposited On:2020-11-30
Last Modified:2021-03-16
Downloads:0

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