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Sex-differential impact of human cytomegalovirus infection on in vitro reactivity to toll-like receptor 2, 4 and 7/8 stimulation in Gambian infants

Citation

Cox, M and Adetifa, JU and Noho-Konteh, F and Sanyang, LC and Drammeh, A and Plebanski, M and Whittle, HC and Rowland-Jones, SL and Robertson, IK and Flanagan, KL, Sex-differential impact of human cytomegalovirus infection on in vitro reactivity to toll-like receptor 2, 4 and 7/8 stimulation in Gambian infants, Vaccines, 8, (3) pp. 1-16. ISSN 2076-393X (2020) [Refereed Article]


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Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/vaccines8030407

Abstract

Human cytomegalovirus (HCMV) infection rates approach 100% by the first year of life in low-income countries. It is not known if this drives changes to innate immunity in early life and thereby altered immune reactivity to infections and vaccines. Given the panoply of sex differences in immunity, it is feasible that any immunological effects of HCMV would differ in males and females. We analysed ex vivo innate cytokine responses to a panel of toll-like receptor (TLR) ligands in 108 nine-month-old Gambian males and females participating in a vaccine trial. We found evidence that HCMV suppressed reactivity to TLR2 and TLR7/8 stimulation in females but not males. This is likely to contribute to sex differences in responses to infections and vaccines in early life and has implications for the development of TLR ligands as vaccine adjuvants. Development of an effective HCMV vaccine would be able to circumvent some of these potentially negative effects of HCMV infection in childhood.

Item Details

Item Type:Refereed Article
Keywords:human cytomegalovirus, human infants, innate immunity, sex differences, vaccination, toll-like receptor, adjuvants, cytokines
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Humoural immunology and immunochemistry
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Robertson, IK (Dr Iain Robertson)
UTAS Author:Flanagan, KL (Dr Katie Flanagan)
ID Code:141862
Year Published:2020
Deposited By:Health Sciences
Deposited On:2020-11-27
Last Modified:2021-02-17
Downloads:3 View Download Statistics

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