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Nerve pathology distinguishes focal motor chronic inflammatory demyelinating polyradiculoneuropathy from multifocal motor neuropathy
Citation
Tracy, JA and Taylor, BV and Kiernan, M and Dyck, PJ and Crum, BA and Mauermann, ML and Amrami, KK and Spinner, RJ and Dyck, PJB, Nerve pathology distinguishes focal motor chronic inflammatory demyelinating polyradiculoneuropathy from multifocal motor neuropathy, Journal of Clinical Neuromuscular Disease, 22, (1) pp. 1-10. ISSN 1522-0443 (2020) [Refereed Article]
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DOI: doi:10.1097/CND.0000000000000279
Abstract
Methods: We describe 3 focal, motor-predominant, representative cases that could be interpreted on clinical and/or electrophysiological grounds as either MMN or focal CIDP, and present pathological findings.
Results: We highlight pathological differences in these cases, and provide an argument that CIDP and MMN are distinct entities with different pathophysiological mechanisms-chronic demyelination for CIDP, and an immune-mediated attack on paranodal motor axons for MMN.
Conclusions: Based on clinical evaluation, electrophysiology, and nerve biopsy pathology, we can divide the conditions into inflammatory demyelinating neuropathy (focal CIDP) versus chronic axonal neuropathy (MMN). The divergent pathological findings provide further evidence that CIDP and MMN are fundamentally different disorders.
Item Details
Item Type: | Refereed Article |
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Keywords: | chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy, peripheral nerve pathology, chronic axonal neuropathy, peripheral neuropathy |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Treatment of human diseases and conditions |
UTAS Author: | Taylor, BV (Professor Bruce Taylor) |
ID Code: | 141819 |
Year Published: | 2020 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2020-11-24 |
Last Modified: | 2020-11-24 |
Downloads: | 0 |
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