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Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome


Bridgeman, SC and Northrop, W and Melton, PE and Ellison, GC and Newsholme, P and Mamotte, CDS, Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome, Pharmacological Research, 160 Article 105174. ISSN 1043-6618 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Elsevier Ltd.

DOI: doi:10.1016/j.phrs.2020.105174


Metabolic syndrome (MetS) and the associated incidence of cardiovascular disease and type 2 diabetes represents a significant contributor to morbidity and mortality worldwide. Butyrate, a short-chain fatty acid produced by the gut microbiome, has long been known to promote growth in farmed animals and more recently has been reported to improve body weight and composition, lipid profile, insulin sensitivity and glycaemia in animal models of MetS. In vitro studies have examined the influence of butyrate on intestinal cells, adipose tissue, skeletal muscle, hepatocytes, pancreatic islets and blood vessels, highlighting genes and pathways that may contribute to its beneficial effects. Butyrate's influences in these cells have been attributed primarily to its epigenetic effects as a histone deacetylase inhibitor, as well as its role as an agonist of free fatty acid receptors, but clear mechanistic evidence is lacking. There is also uncertainty whether results from animal studies can translate to human trials due to butyrate's poor systemic availability and rapid clearance. Hitherto, several small-scale human clinical trials have failed to show significant benefits in MetS patients. Further trials are clearly needed, including with formulations designed to improve butyrate's availability. Regardless, dietary intervention to increase the rate of butyrate production may be a beneficial addition to current treatment. This review outlines the current body of evidence on the suitability of butyrate supplementation for MetS, looking at mechanistic effects on the various components of MetS and highlighting gaps in the knowledge and roadblocks to its use in humans.

Item Details

Item Type:Refereed Article
Keywords:butyrate, diabetes, HDAC inhibitor, metabolic syndrome, short-chain fatty acid
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Melton, PE (Dr Phillip Melton)
ID Code:141793
Year Published:2020
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-11-19
Last Modified:2021-03-11

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