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The global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli in the community

Citation

Bezabih, YW and Sabiiti, W and Alamneh, E and Bezabih, A and Peterson, GM and Bezabhe, WM and Roujeinikova, A, The global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli in the community, Journal of Antimicrobial Chemotherapy, 76, (1) pp. 22-29. ISSN 0305-7453 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 the author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved

DOI: doi:10.1093/jac/dkaa399

Abstract

Objectives: Intestinal colonization by ESBL Escherichia coli and its association with community-acquired MDR infections is of great concern. This review determined the worldwide prevalence of human faecal ESBL E. coli carriage and its trend in the community over the past two decades.

Methods: A systematic literature search was conducted using PubMed, EMBASE and Google Scholar to retrieve articles published between 1 January 2000 and 13 February 2020 that contained data on the prevalence of faecal carriage of ESBL E. coli among healthy individuals. A cumulative (for the whole period) meta-analysis was used to estimate the global and regional pooled prevalence rates. Articles were grouped into study periods of 3 years, and subgroup meta-analyses were undertaken to examine the global pooled prevalence over time.

Results: Sixty-two articles covering 29 872 healthy persons were included in this meta-analysis. The cumulative (200318) global pooled prevalence of ESBL E. coli intestinal carriage in the community was 16.5% (95% CI 14.3%18.7%; P < 0.001). The pooled prevalence showed an upward trend, increasing from 2.6% (95% CI 1.6%4.0%) in 200305 to 21.1% (95% CI 15.8%27.0%) in 201518. Over the whole period, the highest carriage rate was observed in South-East Asia (27%; 95% CI 2.9%51.3%), while the lowest occurred in Europe (6.0%; 95% CI 4.6%7.5%).

Conclusions: Globally, an 8-fold increase in the intestinal carriage rate of ESBL E. coli in the community has occurred over the past two decades. Prevention of its spread may require new therapeutic and public health strategies.

Item Details

Item Type:Refereed Article
Keywords:ESBL
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Alamneh, E (Dr Endalkachew Alamneh)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Bezabhe, WM (Dr Woldesellassie Bezabhe)
ID Code:141790
Year Published:2020
Web of Science® Times Cited:9
Deposited By:Pharmacy
Deposited On:2020-11-19
Last Modified:2021-08-16
Downloads:0

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