Tu, L and Zheng, S and Cicuttini, F and Jin, X and Han, W and Zhu, Z and Antony, B and Winzenberg, T and Jones, G and Gu, J and Wluka, AE and Ding, C, Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis, Arthritis Care & Research Article online ahead of print. ISSN 2151-464X (2020) [Refereed Article]
|PDF (Accepted article)|
This is the peer reviewed version of the following article, which has been published in final form at http://dx.doi.org/10.1002/acr.24371. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12.5 nmol/L to 60 nmol/L were included and randomly allocated to either monthly vitamin D3 or placebo treatment (1:1) for 2 years. Manchester Foot Pain and Disability Index (MFPDI) was used to evaluate foot pain and Disabling foot pain was defined as at least one of the 10 functional limitation items (items 1-9,11) being documented as on 'most/every day(s)' in the last month. A repeated-measure mixed effect model was used to analyze the change of MFPDI scores between groups adjusting for potential confounders.
Results: A total of 413 patients with a mean age of 63.2 years (49.7% males) were enrolled and 340 completed the study. The mean MFPDI score was 22.8±7.3, with 23.7% participants having disabling foot pain at baseline. There were significant differences in MFPDI scores change between groups over 2 years, with more improvements in vitamin D group than in placebo group (-0.03 vs. 1.30, P=0.013) and more improvement in those maintaining sufficient vitamin D levels (n=226) than those who did not (n=114) (-0.09 vs. 2.19, P=0.001).
Conclusion: Vitamin D supplementation and maintenance of sufficient vitamin D levels may improve foot pain in those with knee OA.
|Item Type:||Refereed Article|
|Keywords:||osteoarthritis, foot pain, vitamin D|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Zheng, S (Miss Shuang Zheng)|
|UTAS Author:||Jin, X (Mr Xingzhong Jin)|
|UTAS Author:||Han, W (Dr Weiyu Han)|
|UTAS Author:||Zhu, Z (Mr Zhaohua Zhu)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|UTAS Author:||Winzenberg, T (Professor Tania Winzenberg)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||12 View Download Statistics|
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