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Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis


Tu, L and Zheng, S and Cicuttini, F and Jin, X and Han, W and Zhu, Z and Antony, B and Winzenberg, T and Jones, G and Gu, J and Wluka, AE and Ding, C, Effects of vitamin D supplementation on disabling foot pain in patients with symptomatic knee osteoarthritis, Arthritis Care & Research Article online ahead of print. ISSN 2151-464X (2020) [Refereed Article]

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This is the peer reviewed version of the following article, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

DOI: doi:10.1002/acr.24371


Objectives: This study aims to determine whether vitamin D supplementation or maintaining sufficient vitamin D level reduces foot pain over two years in patients with symptomatic knee OA.

Methods: A post hoc study was conducted from a randomized double-blind placebo-controlled trial named the VItamin D Effect on Osteoarthritis (VIDEO) study. Symptomatic knee OA patients with serum 25-hydroxyvitamin D levels between 12.5 nmol/L to 60 nmol/L were included and randomly allocated to either monthly vitamin D3 or placebo treatment (1:1) for 2 years. Manchester Foot Pain and Disability Index (MFPDI) was used to evaluate foot pain and Disabling foot pain was defined as at least one of the 10 functional limitation items (items 1-9,11) being documented as on 'most/every day(s)' in the last month. A repeated-measure mixed effect model was used to analyze the change of MFPDI scores between groups adjusting for potential confounders.

Results: A total of 413 patients with a mean age of 63.2 years (49.7% males) were enrolled and 340 completed the study. The mean MFPDI score was 22.87.3, with 23.7% participants having disabling foot pain at baseline. There were significant differences in MFPDI scores change between groups over 2 years, with more improvements in vitamin D group than in placebo group (-0.03 vs. 1.30, P=0.013) and more improvement in those maintaining sufficient vitamin D levels (n=226) than those who did not (n=114) (-0.09 vs. 2.19, P=0.001).

Conclusion: Vitamin D supplementation and maintenance of sufficient vitamin D levels may improve foot pain in those with knee OA.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, foot pain, vitamin D
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zheng, S (Miss Shuang Zheng)
UTAS Author:Jin, X (Mr Xingzhong Jin)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:141722
Year Published:2020
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-11-12
Last Modified:2021-04-07
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