Turner, L and Hardikar, A and Jose, MD and Bhattarai, K and Fenton, C and Sharma, R and Kirkland, G and Jeffs, L and Breslin, M and Silva Ragaini, B and Newland, RF, Acute kidney injury, stroke and death after cardiopulmonary bypass surgery: the role of perfusion flow and pressure, Perfusion (United Kingdom) pp. 1-9. ISSN 0267-6591 (2020) [Refereed Article]
Copyright 2020 The Authors
Methods: We identified patients from the Australian and New Zealand Collaborative Perfusion Registry who underwent coronary artery bypass grafting and/or valvular surgery between 2008 and 2018. Primary predictor variables were the length of time the perfusion flow was <1.6 L/min/m2 and the length of time perfusion pressure was < 50mmHg. The primary outcome was new postoperative acute kidney injury defined by the risk-injury-failure-loss-end stage criteria. Secondary outcomes were stroke and in-hospital death. The influence of perfusion flow and pressure during cardiopulmonary bypass on the primary and secondary outcomes was estimated using separate multivariate models.
Results: A total of 16,356 patients were included. The mean age was 66 years and 75% were male. Acute kidney injury was observed in 1,844 patients (11%), stroke in 204 (1.3%) and in-hospital death in 286 (1.8%). Neither the duration of the time spent for perfusion flow (<1.6 L/minute/m2) nor the duration of the time spent for perfusion pressure (<50 mmHg) was associated with postoperative acute kidney injury, stroke or death in adjusted models.
Conclusions: Neither low perfusion pressure nor low perfusion flow during cardiopulmonary bypass were predictive of postoperative acute kidney injury, stroke or death.
|Item Type:||Refereed Article|
|Keywords:||acute kidney injury, cardiopulmonary bypass, perfusion flow, perfusion pressure, stroke|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Nephrology and urology|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Jose, MD (Professor Matthew Jose)|
|UTAS Author:||Kirkland, G (Dr Geoffrey Kirkland)|
|UTAS Author:||Jeffs, L (Dr Lisa Jeffs)|
|UTAS Author:||Breslin, M (Dr Monique Breslin)|
|UTAS Author:||Silva Ragaini, B (Ms Bruna Silva Ragaini)|
|Deposited By:||Menzies Institute for Medical Research|
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