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GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics

Citation

Tintle, NL and Fardo, DW and de Andrade, M and Aslibekyan, S and Bailey, JN and Bermejo, JL and Cantor, RM and Ghosh, S and Melton, P and Wang, X and MacCluer, JW and Almasy, L, GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics, BMC Proceedings, 12, (9) Article 26. ISSN 1753-6561 (2018) [Contribution to Refereed Journal]


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DOI: doi:10.1186/s12919-018-0113-1

Abstract

GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual research groups were extensively discussed prior, during, and after the Workshop in groups based on discussion themes, before being submitted for publication.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:epigenetics, DNA methylation, tiglycerides, family studies, pharmacogenetics
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene mapping
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the mathematical sciences
UTAS Author:Melton, P (Dr Phillip Melton)
ID Code:141480
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-10-22
Last Modified:2021-02-09
Downloads:0

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