eCite Digital Repository
GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics
Citation
Tintle, NL and Fardo, DW and de Andrade, M and Aslibekyan, S and Bailey, JN and Bermejo, JL and Cantor, RM and Ghosh, S and Melton, P and Wang, X and MacCluer, JW and Almasy, L, GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics, BMC Proceedings, 12, (9) Article 26. ISSN 1753-6561 (2018) [Contribution to Refereed Journal]
 | PDF Pending copyright assessment - Request a copy 167Kb |
DOI: doi:10.1186/s12919-018-0113-1
Abstract
GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related
phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In
this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated
by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families
(N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate,
single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of
covariates. The contributions from individual research groups were extensively discussed prior, during, and after the
Workshop in groups based on discussion themes, before being submitted for publication.
Item Details
| Item Type: | Contribution to Refereed Journal |
|---|---|
| Keywords: | epigenetics, DNA methylation, tiglycerides, family studies, pharmacogenetics |
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Gene mapping |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the mathematical sciences |
| UTAS Author: | Melton, P (Dr Phillip Melton) |
| ID Code: | 141480 |
| Year Published: | 2018 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2020-10-22 |
| Last Modified: | 2021-02-09 |
| Downloads: | 0 |
Repository Staff Only: item control page