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Genome-wide association study of autistic-like traits in a general population study of young adults

Citation

Jones, RM and Cadby, G and Melton, PE and Abraham, LJ and Whitehouse, AJ and Moses, EK, Genome-wide association study of autistic-like traits in a general population study of young adults, Frontiers in Human Neuroscience, 7 Article 658. ISSN 1662-5161 (2013) [Refereed Article]


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Copyright Statement

Copyright: © 2013 Jones, Cadby, Melton, Abraham, Whitehouse and Moses. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI: doi:10.3389/fnhum.2013.00658

Abstract

Research has proposed that autistic-like traits in the general population lie on a continuum, with clinical ASD representing the extreme end of this distribution. Inherent in this proposal is that biological mechanisms associated with clinical ASD may also underpin variation in autistic-like traits within the general population. A GWA study using 2,462,046 SNPs was undertaken for ASD in 965 individuals from the Western Australian Pregnancy Cohort (Raine) Study. No SNP associations reached genome-wide significance (p < 5.0 × 10−8). However, investigations into nominal observed SNP associations (p < 1.0 × 10−5) add support to two positional candidate genes previously implicated in ASD etiology, PRKCB1, and CBLN1. The rs198198 SNP (p = 9.587 × 10−6), is located within an intron of the protein kinase C, beta 1 (PRKCB1) gene on chromosome 16p11. The PRKCB1 gene has been previously reported in linkage and association studies for ASD, and its mRNA expression has been shown to be significantly down regulated in ASD cases compared with controls. The rs16946931 SNP (p = 1.78 × 10−6) is located in a region flanking the Cerebellin 1 (CBLN1) gene on chromosome 16q12.1. The CBLN1 gene is involved with synaptogenesis and is part of a gene family previously implicated in ASD. This GWA study is only the second to examine SNPs associated with autistic-like traits in the general population, and provides evidence to support roles for the PRKCB1 and CBLN1 genes in risk of clinical ASD.

Item Details

Item Type:Refereed Article
Keywords:CBLN1; PRKCB1; autism spectrum disorder; autism spectrum quotient; autistic-like traits; genome-wide association
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene mapping
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Melton, PE (Dr Phillip Melton)
ID Code:141457
Year Published:2013
Web of Science® Times Cited:24
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-10-21
Last Modified:2021-05-20
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