Meso_BAP1_exome_2015.pdf (163.2 kB)
Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma
journal contribution
posted on 2023-05-20, 18:47 authored by Sneddon, S, Leon, JS, Dick, IM, Cadby, G, Olsen, N, Brims, F, Allcock, RJN, Moses, EK, Phillip MeltonPhillip Melton, de Klerk, N, Musk, AW, Robinson, BWS, Creaney, JMalignant mesothelioma (MM) is a uniformly fatal tumour caused predominantly by exposure to asbestos. It is not known why some exposed individuals get mesothelioma and others do not. There is some epidemiological evidence of host susceptibility. BAP1 gene somatic mutations and allelic loss are common in mesothelioma and recently a BAP1 cancer syndrome was described in which affected individuals and families had an increased risk of cancer of multiple types, including MM. To determine if BAP1 mutations could underlie any of the sporadic mesothelioma cases in our cohort of patients, we performed targeted deep sequencing of the BAP1 exome on the IonTorrent Proton sequencer in 115 unrelated MM cases. No exonic germline BAP1 mutations of known functional significance were observed, further supporting the notion that sporadic germline BAP1 mutations are not relevant to the genetic susceptibility of MM.
History
Publication title
GeneVolume
563Pagination
103-5ISSN
0378-1119Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Science BvPlace of publication
Po Box 211, Amsterdam, Netherlands, 1000 AeRights statement
2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Repository Status
- Open