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Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems


Justice, AE and Chittoor, G and Gondalia, R and Melton, PE and Lim, E and Grove, ML and Whitsel, EA and Liu, C-T and Cupples, LA and Fernandez-Rhodes, L and Guan, W and Bressler, J and Fornage, M and Boerwinkle, E and Li, Y and Demerath, E and Heard-Costa, N and Levy, D and Stewart, JD and Baccarelli, A and Hou, L and Conneely, K and Mori, MA and Beilin, LJ and Huang, R-C and Gordon-Larsen, P and Howard, AG and North, KE, Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems, Epigenomics, 12, (17) pp. 1483-1499. ISSN 1750-1911 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Future Medicine Ltd.

DOI: doi:10.2217/epi-2019-0276


Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.

Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).

Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.

Item Details

Item Type:Refereed Article
Keywords:DNA methylation, TXNIP, ancestrally diverse, body fat distribution, cardiometabolic disease, central adiposity, methylome-wide association study, waist circumference, waist-to-height ratio, waist-to-hip ratio
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene mapping
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Melton, PE (Dr Phillip Melton)
ID Code:141364
Year Published:2020
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-10-16
Last Modified:2022-08-19

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