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Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

journal contribution
posted on 2023-05-20, 18:38 authored by Justice, AE, Chittoor, G, Gondalia, R, Phillip MeltonPhillip Melton, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, Cupples, LA, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, MA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AG, North, KE

Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.

Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).

Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.

History

Publication title

Epigenomics

Volume

12

Issue

17

Pagination

1483-1499

ISSN

1750-1911

Department/School

Menzies Institute for Medical Research

Publisher

Future Medicine Ltd.

Place of publication

United Kingdom

Rights statement

Copyright 2020 Future Medicine Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified