Armstrong, MK and Schultz, MG and Hughes, AD and Picone, DS and Black, JA and Dwyer, N and Roberts-Thomson, P and Sharman, JE, Excess pressure as an analogue of blood flow velocity, Journal of Hypertension, 38 pp. 1-7. ISSN 0263-6352 (2020) [Refereed Article]
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Methods: Intra-arterial blood pressure was measured sequentially at the brachial and radial arteries via fluid-filled catheter simultaneously with blood flow velocity waveforms recorded via Doppler ultrasound on the contralateral arm (n = 98, aged 61 ± 10 years, 72% men). Excess pressure was derived from intra-arterial blood pressure waveforms using pressure-only reservoir-excess pressure analysis.
Results: Brachial and radial blood flow velocity waveform morphology were closely approximated by excess pressure derived from their respective sites of measurement (median cross-correlation coefficient r = 0.96 and r = 0.95 for brachial and radial comparisons, respectively). In frequency analyses, coherence between blood flow velocity and excess pressure was similar for brachial and radial artery comparisons (brachial and radial median coherence = 0.93 and 0.92, respectively). Brachial and radial blood flow velocity pulse heights were correlated with their respective excess pressure pulse heights (r = 0.53, P < 0.001 and r = 0.43, P < 0.001, respectively).
Conclusion: Excess pressure is an analogue of blood flow velocity, thus affording the opportunity to derive potentially important information related to arterial blood flow using only the blood pressure waveform.
|Item Type:||Refereed Article|
|Keywords:||hemodynamics, invasive, pulse wave analysis|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Armstrong, MK (Mr Matthew Armstrong)|
|UTAS Author:||Schultz, MG (Dr Martin Schultz)|
|UTAS Author:||Picone, DS (Mr Dean Picone)|
|UTAS Author:||Black, JA (Dr Andrew Black)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Deposited By:||Menzies Institute for Medical Research|
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