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A systematic review and meta-analysis of health state utility values for osteoarthritis-related conditions


Zhao, T and Winzenberg, T and de Graaff, B and Aitken, D and Ahmad, H and Palmer, AJ, A systematic review and meta-analysis of health state utility values for osteoarthritis-related conditions, Arthritis Care & Research ISSN 2151-464X (2020) [Refereed Article]

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Copyright Statement

Copyright 2020 American College of Rheumatology. This is the peer reviewed version of the following article, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

DOI: doi:10.1002/acr.24478


Background: Health state utility values (HSUVs) are a key input in health economic modelling but HSUVs of people with osteoarthritis (OA)-related conditions have not been systematically reviewed and meta-analysed.

Objective: To systematically review and meta-analyse the HSUVs for people with OA.

Methods: Searches within health economic/biomedical databases were performed to identify eligible studies reporting OA-related HSUVs. Data on study design, participant characteristics, affected OA joint sites, treatment type, HSUV elicitation method, considered health states, and the reported HSUVs were extracted. HSUVs for people with knee, hip and mixed OA in pre- and post-treatment populations were meta-analysed using random effects models.

Results: One-hundred and fifty-one studies were included in the systematic review, and 88 in meta-analyses. Of 151 studies, 56% were conducted in Europe, 75% were in people with knee and/or hip OA and 79% were based on the EQ-5D. The pooled mean (95% confidence interval [CI]) baseline HSUVs for knee OA core interventions, medication, injection and primary surgery treatments were 0.64 (0.610.66), 0.56 (0.45−0.68), 0.58 (0.500.66) and 0.52 (0.490.55), respectively. These were 0.71 (0.590.84) for hip OA core interventions and 0.52 (0.490.56) for hip OA primary surgery. For all knee OA treatments and hip OA primary surgery, pooled HSUVs were significantly higher in the post- than the pre- treatment populations.

Conclusion: This study provides a comprehensive summary of OA-related HSUVs and generates a HSUVs database for people with different affected OA joint sites undergoing different treatments to guide HSUV choices in future health economic modelling of OA interventions.

Item Details

Item Type:Refereed Article
Keywords:systematic review, health state, utility values, osteoarthritis, health-economics; HSUVs, HRQoL, quality of Life
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Health services and systems not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Zhao, T (Dr Ting Zhao)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:de Graaff, B (Dr Barbara de Graaff)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Ahmad, H (Dr Hasnat Ahmad)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:141235
Year Published:2020
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-10-07
Last Modified:2021-05-19
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