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Mechanisms targeting the unfolded protein response in asthma

Citation

Dastghaib, S and Kumar, S and Aftabi, S and Damera, G and Dalvand, A and Sepanjnia, A and Kiumarsi, M and Aghanoori, M-R and Sohal, SS and Ande, SR and Alizadeh, J and Mokarram, P and Ghavami, S and Sharma, P and Zeki, AA, Mechanisms targeting the unfolded protein response in asthma, American Journal of Respiratory Cell and Molecular Biology ISSN 1044-1549 (2021) [Refereed Article]


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Copyright 2020 American Thoracic Society

DOI: doi:10.1165/rcmb.2019-0235TR

Abstract

Lung cells are constantly exposed to various internal and external stressors that disrupt protein homeostasis. To cope with these stimuli, cells evoke a highly conserved adaptive mechanism called the unfolded protein response (UPR). UPR stressors can impose greater protein secretory demands on the endoplasmic reticulum (ER) resulting in the development, differentiation, and survival of these cell types to meet these increasing functional needs. Dysregulation of the UPR leads to the development of the disease. The UPR and ER stress are involved in several human conditions such as chronic inflammation, neurodegeneration, metabolic syndrome, and cancer. Further, potent and specific compounds that target the UPR pathway are under development as future therapies. The focus of this review is to thoroughly describe the effects of both internal and external stressors on the ER in asthma. Further, we discuss how the UPR signaling pathway is activated in the lungs to overcome cellular damage. We also present an overview of the pathogenic mechanisms with a brief focus on potential strategies for pharmacological interventions.

Item Details

Item Type:Refereed Article
Keywords:asthma, ER stress, endoplasmic reticulum (ER), unfolded protein response
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:141207
Year Published:2021
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2020-10-04
Last Modified:2021-01-12
Downloads:0

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