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Diagnostic approaches in COVID-19: clinical updates


Asrani, P and Eapen, MS and Chia, C and Haug, G and Weber, HC and Hassan, Md Imtaiyaz and Sohal, SS, Diagnostic approaches in COVID-19: clinical updates, Expert Review of Respiratory Medicine, 15, (2) pp. 197-212. ISSN 1747-6348 (2021) [Refereed Article]

Copyright Statement

Copyright 2020 Informa UK Limited, trading as Taylor & Francis Group

DOI: doi:10.1080/17476348.2021.1823833


Introduction: COVID-19 is a recent emerging pandemic whose prognosis is still unclear. Diagnostic tools are the main players that not only indicate a possible infection but can further restrict the transmission and can determine the extent to which disease progression would occur.

Areas covered: In this paper, we have performed a narrative and critical review on different technology-based diagnostic strategies such as molecular approaches including real-time reverse transcriptase PCR, serological testing through enzyme-linked immunosorbent assay, laboratory and point of care devices, radiology-based detection through computed tomography and chest X-ray, and viral cell cultures on Vero E6 cell lines are discussed in detail to address COVID-19. This review further provides an overview of emergency use authorized immunodiagnostic and molecular diagnostic kits and POC devices by FDA for timely and efficient conduction of diagnostic tests. The majority of the literature cited in this paper is collected from guidelines on protocols and other considerations on diagnostic strategies of COVID-19 issued by WHO, CDC, and FDA under emergency authorization.

Expert opinion: Such information holds importance to the health professionals in conducting error-free diagnostic tests and researches in producing better clinical strategies by addressing the limitations associated with the available methods.

Item Details

Item Type:Refereed Article
Keywords:COVID-19, SARS-CoV-2, immunodiagnostics, point of care, serological testing, radiology, viral cell culture, rRT-PCR
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Eapen, MS (Dr Mathew Eapen)
UTAS Author:Haug, G (Dr Greg Haug)
UTAS Author:Weber, HC (Associate Professor Heinrich Weber)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:141205
Year Published:2021
Web of Science® Times Cited:32
Deposited By:Health Sciences
Deposited On:2020-10-04
Last Modified:2022-08-25

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