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Microbiota modulating nutritional approaches to countering the effects of viral respiratory infections including SARS-CoV-2 through promoting metabolic and immune fitness with probiotics and plant bioactives
Citation
Shinde, TS and Hansbro, PM and Sohal, SS and Dingle, P and Eri, R and Stanley, R, Microbiota modulating nutritional approaches to countering the effects of viral respiratory infections including SARS-CoV-2 through promoting metabolic and immune fitness with probiotics and plant bioactives, Microorganisms, 8, (6) Article 921. ISSN 2076-2607 (2020) [Refereed Article]
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Copyright Statement
Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.3390/microorganisms8060921
Abstract
Viral respiratory infections (VRIs) can spread quickly and cause enormous morbidity
and mortality worldwide. These events pose serious threats to public health due to time lags in
developing vaccines to activate the acquired immune system. The high variability of people’s
symptomatic responses to viral infections, as illustrated in the current COVID-19 pandemic, indicates
the potential to moderate the severity of morbidity from VRIs. Growing evidence supports roles
for probiotic bacteria (PB) and prebiotic dietary fiber (DF) and other plant nutritional bioactives
in modulating immune functions. While human studies help to understand the epidemiology and
immunopathology of VRIs, the chaotic nature of viral transmissions makes it difficult to undertake
mechanistic study where the pre-conditioning of the metabolic and immune system could be
beneficial. However, recent experimental studies have significantly enhanced our understanding of
how PB and DF, along with plant bioactives, can significantly modulate innate and acquired immunity
responses to VRIs. Synbiotic combinations of PB and DF potentiate increased benefits primarily
through augmenting the production of short-chain fatty acids (SCFAs) such as butyrate. These and
specific plant polyphenolics help to regulate immune responses to both restrain VRIs and temper
the neutrophil response that can lead to acute respiratory distress syndrome (ARDS). This review
highlights the current understanding of the potential impact of targeted nutritional strategies in
setting a balanced immune tone for viral clearance and reinforcing homeostasis. This knowledge may
guide the development of public health tactics and the application of functional foods with PB and
DF components as a nutritional approach to support countering VRI morbidity
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | COVID-19, dietary fiber, innate immune response, probiotic, synbiotic, functional foods, short-chain fatty acids (SCFAs), dysbiosis, gut microbiota |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Shinde, TS (Ms Tanvi Shinde) |
| UTAS Author: | Sohal, SS (Dr Sukhwinder Sohal) |
| UTAS Author: | Eri, R (Associate Professor Raj Eri) |
| UTAS Author: | Stanley, R (Professor Roger Stanley) |
| ID Code: | 141201 |
| Year Published: | 2020 |
| Web of Science® Times Cited: | 35 |
| Deposited By: | Health Sciences |
| Deposited On: | 2020-10-04 |
| Last Modified: | 2022-08-25 |
| Downloads: | 18 View Download Statistics |
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