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Brain-derived neurotropic factor and cortisol levels negatively predict working memory performance in healthy males

Citation

Ney, L and Felmingham, K and Nichols, DS and Matthews, A, Brain-derived neurotropic factor and cortisol levels negatively predict working memory performance in healthy males, Neurobiology of Learning and Memory, 175 Article 107308. ISSN 1074-7427 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Published by Elsevier Inc.

DOI: doi:10.1016/j.nlm.2020.107308

Abstract

There is now significant literature suggesting that increasing brain-derived neurotropic factor (BDNF) signalling may improve memory-related disorders such as Alzheimer’s disease. However, the effects of BDNF on short-term and working memory are not clear and existing evidence is inconsistent. Here we measured plasma BDNF and salivary cortisol levels, as well as working memory, on an N-Back task before and after mixed psychosocial/physiological stress induction in healthy males (N=29). Stress induction was associated with higher circulating cortisol, but not BDNF levels. Higher cortisol and BDNF levels were significantly associated with poorer accuracy before and after stress induction. There was also a significant interaction, such that higher BDNF was associated with a buffering effect on the negative association between high cortisol and working memory. Future studies should replicate this data in larger samples, with emphasis on cortisol/BDNF interactions in determining working memory performance.

Item Details

Item Type:Refereed Article
Keywords:brain-derived neurotrophic factor, working memory, acute stress, cortisol, BDNF
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Ney, L (Mr Luke Ney)
UTAS Author:Felmingham, K (Professor Kim Felmingham)
UTAS Author:Nichols, DS (Dr David Nichols)
UTAS Author:Matthews, A (Dr Allison Matthews)
ID Code:140600
Year Published:2020
Web of Science® Times Cited:1
Deposited By:Psychology
Deposited On:2020-08-30
Last Modified:2021-04-26
Downloads:0

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