Orchard, SG and Lockery, JE and Gibbs, P and Polekhina, G and Wolfe, R and Zalcberg, J and Haydon, A and McNeil, JJ and Nelson, MR and Reid, CM and Kirpach, B and Murray, AM and Woods, RL, on behalf of the ASPREE Investigator Group, Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial, Contemporary Clinical Trials, 96 Article 106095. ISSN 1551-7144 (2020) [Refereed Article]
© 2020 Elsevier Inc. All rights reserved.
Methods: At study enrolment (2010-2014), self-reported personal cancer history, cancer type and cancer risk factor data were sought from 19,114 participants (Australia, n = 16,703; U.S., n = 2411). Eligible participants were healthy, free of major diseases and expected to survive 5 years.
Results: Nearly 20% of enrolling ASPREE participants reported a prior cancer diagnosis; 18% of women and 22% of men, with women diagnosed younger (16% vs 6% of diagnoses <50 years). Cancer prevalence increased with age. Prevalence of prostate and breast cancer history were higher in U.S. participants; melanoma and colorectal cancer were higher in Australian participants. Cancer history prevalence was not associated with contemporary common risk factors nor previous aspirin use, but was associated with poor health ratings in men. Blood and breast cancer history were more common with past aspirin use.
Conclusions: Personal cancer history in healthy older ASPREE participants was as expected for the most common cancer types in the respective populations, but was not necessarily aligned with known risk factors. We attribute this to survivor bias, likely driven by entry criteria.
|Item Type:||Refereed Article|
|Keywords:||aspirin, cancer epidemiology, cancer prevalence, cancer risk factors, selection criteria, survivor bias|
|Research Division:||Health Sciences|
|Research Field:||Epidemiology not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Nelson, MR (Professor Mark Nelson)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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