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Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial
Methods: At study enrolment (2010-2014), self-reported personal cancer history, cancer type and cancer risk factor data were sought from 19,114 participants (Australia, n = 16,703; U.S., n = 2411). Eligible participants were healthy, free of major diseases and expected to survive 5 years.
Results: Nearly 20% of enrolling ASPREE participants reported a prior cancer diagnosis; 18% of women and 22% of men, with women diagnosed younger (16% vs 6% of diagnoses <50 years). Cancer prevalence increased with age. Prevalence of prostate and breast cancer history were higher in U.S. participants; melanoma and colorectal cancer were higher in Australian participants. Cancer history prevalence was not associated with contemporary common risk factors nor previous aspirin use, but was associated with poor health ratings in men. Blood and breast cancer history were more common with past aspirin use.
Conclusions: Personal cancer history in healthy older ASPREE participants was as expected for the most common cancer types in the respective populations, but was not necessarily aligned with known risk factors. We attribute this to survivor bias, likely driven by entry criteria.
History
Publication title
Contemporary Clinical TrialsVolume
96Article number
106095Number
106095Pagination
1-7ISSN
1551-7144Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Inc.Place of publication
United StatesRights statement
© 2020 Elsevier Inc. All rights reserved.Repository Status
- Restricted