Salehi-Sahlabadi, A and Varkaneh, HK and Shahdadian, F and Ghaedi, E and Nouri, M and Singh, A and Farhadnejad, H and Gaman, MA and Hekmatdoost, A and Mirmiran, P, Effects of Phytosterols supplementation on blood glucose, glycosylated hemoglobin (HbA1c) and insulin levels in humans: a systematic review and meta-analysis of randomized controlled trials, Journal of Diabetes and Metabolic Disorders, 19, (1) pp. 625-632. ISSN 2251-6581 (2020) [Refereed Article]
Copyright Springer Nature Switzerland AG 202
Methods: A comprehensive search was conducted to identify all RCTs published up to May 2019 in the following databases: PubMed-MEDLINE, Web of Science, Cochrane Library and Scopus. The mean difference with 95% confidence intervals (CIs) was pooled using a random-effects model (DerSimonian-Laird method).
Results: Twenty-six arms from 20 RCTs were included in the present meta-analysis. Our findings show that PS supplementation decreases insulin levels (mean difference [MD]: -6.426 μU/ml, 95% CI: -7.187, -5.665, P- value = 0.000). However, PS supplementation did not have significant effects on FBS and HbA1c levels. Following PS supplementation, significant changes in FBS (mean difference [MD]: -1.942 mg/dl, 95% CI: -3.637, -0.246, P- value = 0.025) and HbA1c (mean difference [MD]: -0.059%, 95% CI: -0.114, -0.004, P- value = 0.035) based on PS dosage (mg/d) were recorded.
Conclusions: In patients with a baseline BMI <25 kg/m2, PS consumption significantly increased FBS levels. Patients who consumed 1-2 g/day of PS had a lower FBS and lower HbA1c levels.
|Item Type:||Refereed Article|
|Keywords:||fasting blood sugar, glycosylated hemoglobin, insulin, Phytosterol|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Singh, A (Mr Ambrish Singh)|
|Web of Science® Times Cited:||5|
|Deposited By:||Menzies Institute for Medical Research|
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