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Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?

Citation

Ngui, IQH and Perera, AP and Eri, R, Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?, Molecules, 25, (10) pp. 1-25. ISSN 1420-3049 (2020) [Refereed Article]


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Copyright Statement

Copyright This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/molecules25102427

Abstract

Inflammation is a hallmark in many forms of cancer; with colitis-associated colorectal cancer (CAC) being a progressive intestinal inflammation due to inflammatory bowel disease (IBD). While this is an exemplification of the negatives of inflammation, it is just as crucial to have some degree of the inflammatory process to maintain a healthy immune system. A pivotal component in the maintenance of such intestinal homeostasis is the innate immunity component, inflammasomes. Inflammasomes are large, cytosolic protein complexes formed following stimulation of microbial and stress signals that lead to the expression of pro-inflammatory cytokines. The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been extensively studied in part due to its strong association with colitis and CAC. The aryl hydrocarbon receptor (AhR) has recently been acknowledged for its connection to the immune system aside from its role as an environmental sensor. AhR has been described to play a role in the inhibition of the NLRP3 inflammasome activation pathway. This review will summarise the signalling pathways of both the NLRP3 inflammasome and AhR; as well as new-found links between these two signalling pathways in intestinal immunity and some potential therapeutic agents that have been found to take advantage of this link in the treatment of colitis and CAC.

Item Details

Item Type:Refereed Article
Keywords:aryl hydrocarbon receptor, NLRP3 inflammasome, colitis, colon cancer, NF-κB
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer diagnosis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ngui, IQH (Mr Ivan Ngui)
UTAS Author:Perera, AP (Mrs Agampodi Perera)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:140407
Year Published:2020
Web of Science® Times Cited:3
Deposited By:Health Sciences
Deposited On:2020-08-14
Last Modified:2021-04-20
Downloads:7 View Download Statistics

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