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Is dietary vitamin A associated with myopia from adolescence to young adulthood?


Ng, FJ and Mackey, DA and O'Sullivan, TA and Oddy, WH and Yazar, S, Is dietary vitamin A associated with myopia from adolescence to young adulthood?, Translational Vision Science & Technology, 9, (6) Article 29. ISSN 2164-2591 (2020) [Refereed Article]


Copyright Statement

Copyright 2020 the authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

DOI: doi:10.1167/tvst.9.6.29


Purpose: Potential links may exist between vitamin A intake and myopia via various pathways. In this study, we examined the association between dietary vitamin A intake during adolescence and myopia in early adulthood.

Methods: We performed a prospective analysis utilizing data collected from participants of the Raine Study Gen2. Dietary vitamin A intake, determined via food frequency questionnaires completed at ages 14, 17, and 20 years, was compared with ophthalmic measurements collected at year 20. Low vitamin A levels were defined as <600 μg/day. Regression models were used to adjust for ocular sun exposure level, educational level, and parental myopia as potential confounders.

Results: A total of 642 subjects were analyzed. Although those with adequate vitamin A intakes were less likely to be myopic (P = 0.03), this association became insignificant when adjusted for potential confounding factors in logistic regression modeling (odds ratio, 0.59; 95% confidence interval, 0.982.52; P = 0.06).

Conclusions: There were no significant associations between total vitamin A intakes during adolescence and year 20 refractive errors after adjustment for confounders. Replication of this finding and further investigations are essential to rule out the suggestion that sufficient vitamin A intake during adolescence is associated with lower risk of myopia in early adulthood.

Translational Relevance: Our findings are not definitive that ingesting foods high in vitamin A during childhood and adolescence does not have a role for preventing myopia in early adulthood.

Item Details

Item Type:Refereed Article
Keywords:vitamin A, vitamin A deficiency, myopia, nearsightedness
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutrigenomics and personalised nutrition
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:140395
Year Published:2020
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-08-13
Last Modified:2022-08-29
Downloads:14 View Download Statistics

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