Pridmore, S and Rybak, M and Morey, R and May, T, The impact of transcranial magnetic stimulation (TMS) on irritability occurring with acute major depressive disorder (MDD), Australasian Psychiatry, 29, (2) pp. 218-221. ISSN 1039-8562 (2020) [Refereed Article]
Copyright 2020 The Royal Australian and New Zealand College of Psychiatrists
Objective: To examine the impact (if any) of a course of transcranial magnetic stimulation (TMS) on irritability occurring in association with acute major depressive disorder (MDD).
Method: In a naturalistic study, patients with MDD according to DSM-5 criteria were given 20 daily TMS treatments. A visual analogue scale for irritability (VAS-I) was developed. Objective tools included the six-item Hamilton Depression Rating Scale (HAMDS6) and the Clinical Global Impression - Severity (CGI-S).
Results: Fifty patients received 53 courses. Forty-seven courses achieved remission on both HAMD6 and CGI-S and six courses did not achieve remission with either. Irritability significantly reduced when MDD remission was achieved but was unchanged when remission was not achieved.
Conclusion: TMS reduces irritability occurring in association with MDD when this treatment affects MDD remission, but not when remission is not affected.
|Item Type:||Refereed Article|
|Keywords:||transcranial magnetic stimulation, major depressive disorder, irritability|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Mental health services|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Pridmore, S (Professor Saxby Pridmore)|
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