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The impact of transcranial magnetic stimulation (TMS) on irritability occurring with acute major depressive disorder (MDD)

Citation

Pridmore, S and Rybak, M and Morey, R and May, T, The impact of transcranial magnetic stimulation (TMS) on irritability occurring with acute major depressive disorder (MDD), Australasian Psychiatry, 29, (2) pp. 218-221. ISSN 1039-8562 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 The Royal Australian and New Zealand College of Psychiatrists

DOI: doi:10.1177/1039856220946606

Abstract

Objective: To examine the impact (if any) of a course of transcranial magnetic stimulation (TMS) on irritability occurring in association with acute major depressive disorder (MDD).

Method: In a naturalistic study, patients with MDD according to DSM-5 criteria were given 20 daily TMS treatments. A visual analogue scale for irritability (VAS-I) was developed. Objective tools included the six-item Hamilton Depression Rating Scale (HAMDS6) and the Clinical Global Impression - Severity (CGI-S).

Results: Fifty patients received 53 courses. Forty-seven courses achieved remission on both HAMD6 and CGI-S and six courses did not achieve remission with either. Irritability significantly reduced when MDD remission was achieved but was unchanged when remission was not achieved.

Conclusion: TMS reduces irritability occurring in association with MDD when this treatment affects MDD remission, but not when remission is not affected.

Item Details

Item Type:Refereed Article
Keywords:transcranial magnetic stimulation, major depressive disorder, irritability
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Pridmore, S (Professor Saxby Pridmore)
ID Code:140370
Year Published:2020
Deposited By:Medicine
Deposited On:2020-08-11
Last Modified:2021-09-28
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