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High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis

Citation

Simpson-Yap, S and Oddy, WH and Taylor, B and Lucas, RM and Black, LJ and Ponsonby, A-L and Blizzard, L and van der Mei, I, Ausimmune/AusLong Investigators Group, High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis, Multiple Sclerosis Journal pp. 1-13. ISSN 1352-4585 (2020) [Refereed Article]


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Copyright Statement

The Author(s), 2020. The article has been accepted for publication.

DOI: doi:10.1177/1352458520943087

Abstract

Background: Dietary patterns and their association with subsequent clinical course have not been well studied in early multiple sclerosis (MS).

Objectives: To describe dietary patterns in people in 5 years following first clinical demyelination and assess associations with MS conversion and relapse.

Methods: This study included baseline food frequency questionnaire dietary intake (entry to the Ausimmune Study) and 5-year follow-up; iterated principal factor analysis was applied. MS conversion and relapse risks were assessed by Cox proportional hazards models, adjusted for age, sex, study site, education, body mass index (BMI), smoking and omega-3 supplement use.

Results: In cases with a first clinical diagnosis of central nervous system (CNS) demyelination, we identified three major dietary patterns, 'Prudent', 'High-Vegetable' and 'Mixed', explaining 43%, 37% and 24% of diet variance in dietary intake, respectively. Fruits, vegetables, fish, wholegrains and nuts loaded highly on the Prudent pattern, starchy vegetables and legumes on the High-Vegetable pattern, and meats and alcohol on the Mixed pattern. Diet factor scores were not associated with MS conversion risk. Those with baseline Prudent scores above the median had significantly lower relapse risk (adjusted hazard ratio = 0.54, 95% confidence interval (CI) 0.37, 0.81) with some evidence of a plateau effect.

Conclusion: Prudent diet factor score above the median was prospectively associated with lower relapse risk in the 5 years following the first clinical demyelinating event.

Item Details

Item Type:Refereed Article
Keywords:dietary patterns, multiple sclerosis, factor analysis, MS conversion, relapse
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Simpson-Yap, S (Dr Steve Simpson JR)
UTAS Author:Oddy, WH (Professor Wendy Oddy)
UTAS Author:Taylor, B (Professor Bruce Taylor)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:140317
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-08-06
Last Modified:2020-09-10
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