Wu, J and Jelinek, GA and Weiland, T and Hedstrom, AK and Alfredsson, L and Neate, S and De Livera, A and Nag, N and Simpson-Yap, S, Perceived cognitive impairment is associated with sexual dysfunction in people with multiple sclerosis: a 2.5-year follow-up study of a large international cohort, Multiple Sclerosis and Related Disorders, 45 Article 102410. ISSN 2211-0348 (2020) [Refereed Article]
Copyright 2020 Elsevier BV
Objectives: To explore the relationship between cognitive impairment and sexual dysfunction over 2.5 years in people with MS.
Methods: Data were derived from the Health Outcomes and Lifestyle In a Sample of people with Multiple sclerosis (HOLISM) international cohort over 2.5 years' follow-up. Cognitive function and sexual function were assessed by sub-scores of the MS Quality of Life-54. The impact of perceived cognitive impairment on sexual dysfunction was assessed by calculating prevalence ratios (PR) and relative risks (RR) with 95% confidence intervals (CI) using log-binomial regression models.
Results: 1958 participants were included at baseline, of whom 555 without perceived cognitive impairment at baseline comprised the longitudinal cohort. The prevalence of perceived cognitive impairment at baseline was 45.6%. At baseline, cognitive impairment was associated with increased frequency of self-reported sexual dysfunction (aPR=1.32, 95% CI: 1.17-1.48). Among the sample without sexual dysfunction at baseline, incident sexual dysfunction was more common among participants with persistent (aRR=1.61, 95% CI: 1.06-3.18) and newly reported cognitive impairment (aRR=1.89, 95% CI: 1.14-3.14).
Conclusion: Results suggest PCI may be an independent risk factor for sexual dysfunction in PwMS, which may represent an additional dimension whereby MS may adversely affect quality of life.
|Item Type:||Refereed Article|
|Keywords:||cognitive impairment, longitudinal study, multiple sclerosis, quality of life, sexual dysfunction|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Central nervous system|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Simpson-Yap, S (Dr Steve Simpson JR)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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