Pridmore, S and Turnier-Shea, Y and Erger, S and May, T, The impact of cluster maintenance TMS' on irritability occurring in major depressive disorder, Australasian Psychiatry pp. 1-4. ISSN 1039-8562 (2020) [Contribution to Refereed Journal]
Objective: To determine the impact of clustered maintenance transcranial magnetic stimulation (TMS) on irritability occurring in treatment-resistant major depressive disorder (MDD).
Method: A naturalistic study of 106 courses that includes pre- and posttreatment assessments of subjective and objective depression and a subjective measure of irritability developed for this study.
Results: Forty-six participants (35 females), mean age 43.2 years (14.3), completed 106 courses. There was a significant reduction in irritability and depression scores (p < .001). The change in irritability scores was significantly correlated with the change in depression scores, r = .40, p < .001.
Conclusion: TMS has the capacity to reduce the irritability co-occurring with treatment-resistant MDD, known to be responsive to TMS. This increases the possibility of using TMS in the treatment of irritability co-occurring with other disorders or standing alone (should irritability be categorized as a stand-alone disorder).
|Item Type:||Contribution to Refereed Journal|
|Keywords:||transcranial magnetic stimulation, major depressive disorder, irritability|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Mental health services|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Pridmore, S (Professor Saxby Pridmore)|
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