Asymptomatic left ventricular diastolic dysfunction (ALVDD) (diastolic abnormalities and normal ejection fraction in the absence of symptoms) is associated with incident heart failure (HF) and decreased survival. Abnormalities of diastolic function might therefore be included in the definition of stage B HF, which denotes individuals at risk for the development of HF. Imaging techniques, especially echocardiography, are necessary for the recognition of preclinical left ventricular (LV) diastolic disturbances, as well as further tracking of pathological changes and responses to treatment. The transition of ALVDD to symptomatic HF is underlain by multiple factors, including both cardiovascular and noncardiovascular determinants. The initiation of management strategies targeting cardiovascular and systemic comorbidities in patients identified as having ALVDD may delay symptomatic progression and improve prognosis.

Item Type:	Refereed Article
Keywords:	global longitudinal strain, heart failure with preserved ejection fraction, left ventricular diastolic dysfunction, stage B heart failure
Research Division:	Biomedical and Clinical Sciences
Research Group:	Cardiovascular medicine and haematology
Research Field:	Cardiology (incl. cardiovascular diseases)
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Kosmala, W (Professor Wojciech Kosmala)
UTAS Author:	Marwick, TH (Professor Tom Marwick)
ID Code:	140190
Year Published:	2020
Web of Science® Times Cited:	38
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2020-07-30
Last Modified:	2022-08-25
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