Ma, C and Wu, F and Pan, F and Laslett, L and Shah, A and Squibb, K and Winzenberg, T and Jones, G, Bone microarchitecture, volumetric or areal bone mineral density for discrimination of vertebral deformity in adults: a cross-sectional study, Journal of Clinical Densitometry pp. 1-10. ISSN 1094-6950 (2020) [Refereed Article]
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Copyright 2020 Published by Elsevier Inc. on behalf of The International Society for Clinical Densitometry
Methods: Data on 196 subjects (mean age (standard deviation, SD) = 72 (7) years, female 46%) were utilized. VD of T4-L4 and spine aBMD were measured using dual-energy X-ray absorptiometry. VD was defined if anterior to posterior height ratio was more than 3-SD, 4-SD below, or >25% decrease compared with the sex-matched normal means. Bone microarchitecture parameters at distal radius were collected using high-resolution peripheral quantitative computed tomography and analyzed using StrAx.
Results: The strongest associations were seen for the cortical thickness (odds ratios (ORs): 2.63/SD decrease for 25% and 2.38/SD decrease for 3-SD criterion) and compact cortical area (OR: 3.33/SD decrease for 4-SD criterion). The area under the receiver operating characteristic curve (AUC) for spine aBMD for VD was 0.594, 0.597, and 0.634 for 25%, 3-SD and 4-SD criteria, respectively (all p < 0.05). Compact cortical area, cortical thickness and compact cortical thickness alone had the largest AUCs for VD (0.680-0.685 for 25% criterion, 0.659-0.674 for 3-SD criterion, and 0.699-0.707 for 4-SD criterion). Adding spine aBMD or radial vBMD to each cortical measure did not improve VD discrimination (∆ AUC 0.8%-2.1%).
Conclusions: Cortical measures had the best utility for discriminating VD when used alone. Adding either spine aBMD or radial vBMD did not improve the utility of cortical measures.
|Item Type:||Refereed Article|
|Keywords:||discrimination, dual-energy X-ray absorptiometry, high-resolution peripheral quantitative computed tomography, vertebral deformity|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Ma, C (Ms Canchen Ma)|
|UTAS Author:||Wu, F (Dr Feitong Wu)|
|UTAS Author:||Pan, F (Dr Feng Pan)|
|UTAS Author:||Laslett, L (Dr Laura Laslett)|
|UTAS Author:||Shah, A (Mr Anuj Shah)|
|UTAS Author:||Squibb, K (Dr Kathryn Squibb)|
|UTAS Author:||Winzenberg, T (Professor Tania Winzenberg)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||25 View Download Statistics|
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