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Bone microarchitecture, volumetric or areal bone mineral density for discrimination of vertebral deformity in adults: a cross-sectional study
Citation
Ma, C and Wu, F and Pan, F and Laslett, L and Shah, A and Squibb, K and Winzenberg, T and Jones, G, Bone microarchitecture, volumetric or areal bone mineral density for discrimination of vertebral deformity in adults: a cross-sectional study, Journal of Clinical Densitometry pp. 1-10. ISSN 1094-6950 (2020) [Refereed Article]
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Copyright Statement
Copyright 2020 Published by Elsevier Inc. on behalf of The International Society for Clinical Densitometry
DOI: doi:10.1016/j.jocd.2020.05.005
Abstract
Methods: Data on 196 subjects (mean age (standard deviation, SD) = 72 (7) years, female 46%) were utilized. VD of T4-L4 and spine aBMD were measured using dual-energy X-ray absorptiometry. VD was defined if anterior to posterior height ratio was more than 3-SD, 4-SD below, or >25% decrease compared with the sex-matched normal means. Bone microarchitecture parameters at distal radius were collected using high-resolution peripheral quantitative computed tomography and analyzed using StrAx.
Results: The strongest associations were seen for the cortical thickness (odds ratios (ORs): 2.63/SD decrease for 25% and 2.38/SD decrease for 3-SD criterion) and compact cortical area (OR: 3.33/SD decrease for 4-SD criterion). The area under the receiver operating characteristic curve (AUC) for spine aBMD for VD was 0.594, 0.597, and 0.634 for 25%, 3-SD and 4-SD criteria, respectively (all p < 0.05). Compact cortical area, cortical thickness and compact cortical thickness alone had the largest AUCs for VD (0.680-0.685 for 25% criterion, 0.659-0.674 for 3-SD criterion, and 0.699-0.707 for 4-SD criterion). Adding spine aBMD or radial vBMD to each cortical measure did not improve VD discrimination (∆ AUC 0.8%-2.1%).
Conclusions: Cortical measures had the best utility for discriminating VD when used alone. Adding either spine aBMD or radial vBMD did not improve the utility of cortical measures.
Item Details
Item Type: | Refereed Article |
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Keywords: | discrimination, dual-energy X-ray absorptiometry, high-resolution peripheral quantitative computed tomography, vertebral deformity |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Ma, C (Miss Canchen Ma) |
UTAS Author: | Wu, F (Dr Feitong Wu) |
UTAS Author: | Pan, F (Dr Feng Pan) |
UTAS Author: | Laslett, L (Dr Laura Laslett) |
UTAS Author: | Shah, A (Mr Anuj Shah) |
UTAS Author: | Squibb, K (Dr Kathryn Squibb) |
UTAS Author: | Winzenberg, T (Professor Tania Winzenberg) |
UTAS Author: | Jones, G (Professor Graeme Jones) |
ID Code: | 139991 |
Year Published: | 2020 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2020-07-22 |
Last Modified: | 2020-08-05 |
Downloads: | 8 View Download Statistics |
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