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Multifocal motor neuropathy: controversies and priorities
Citation
Yeh, WZ and Dyck, PJ and van den Berg, LH and Kiernan, MC and Taylor, BV, Multifocal motor neuropathy: controversies and priorities, Journal of Neurology, Neurosurgery and Psychiatry, 91, (2) pp. 140-148. ISSN 0022-3050 (2020) [Refereed Article]
Copyright Statement
© Author(s) (or their employer(s)) 2020.
DOI: doi:10.1136/jnnp-2019-321532
Abstract
Despite 30 years of research there are still significant unknowns and controversies associated with multifocal motor neuropathy (MMN) including disease pathophysiology, diagnostic criteria and treatment. Foremost relates to the underlying pathophysiology, specifically whether MMN represents an axonal or demyelinating neuropathy and whether the underlying pathophysiology is focused at the node of Ranvier. In turn, this discussion promotes consideration of therapeutic approaches, an issue that becomes more directed in this evolving era of precision medicine. It is generally accepted that MMN represents a chronic progressive immune-mediated motor neuropathy clinically characterised by progressive asymmetric weakness and electrophysiologically by partial motor conduction block. Anti-GM1 IgM antibodies are identified in at least 40% of patients. There have been recent developments in the use of neuromuscular ultrasound and MRI to aid in diagnosing MMN and in further elucidation of its pathophysiological mechanisms. The present Review will critically analyse the knowledge accumulated about MMN over the past 30 years, culminating in a state-of-the-art approach to therapy.
Item Details
Item Type: | Refereed Article |
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Keywords: | ganglioside, neuroimmunology, neuropathy, neurophysiology, peripheral neuropathology |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Taylor, BV (Professor Bruce Taylor) |
ID Code: | 139931 |
Year Published: | 2020 |
Web of Science® Times Cited: | 22 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2020-07-16 |
Last Modified: | 2022-08-23 |
Downloads: | 0 |
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