Hussain, S and Singh, A and Baxi, H and Taylor, B and Burgess, J and Antony, B, Thiazolidinedione use is associated with reduced risk of Parkinson's disease in patients with diabetes: a meta-analysis of real-world evidence, Neurological Sciences pp. 1-7. ISSN 1590-1874 (2020) [Refereed Article]
Copyright 2020 Fondazione SocietÓ Italiana di Neurologia
Method: A literature search was performed in PubMed, Embase, and Cochrane central from inception to until 30 September 2019. We included all real-world evidence studies assessing the use of TZD class of drugs and the risk of PD in people with diabetes. Quality of the studies was evaluated using the Newcastle-Ottawa scale. The primary outcome was the pooled hazard ratio (HR) of PD among type 2 DM TZD users as compared with TZD non-users in people with diabetes. The secondary outcome was the HR of PD among type 2 DM TZD users as compared with non-users (include both diabetic and nondiabetic population). Meta-analysis was performed using RevMan software.
Results: Out of five studies selected for inclusion, four studies fulfilled the criteria for primary outcomes. The participants' mean age and follow-up duration were 66.23 ▒ 9.59 years and 5.25 years (2.97-7.9 years), respectively. There was a significant reduction in the risk of PD (pooled adjusted HR of 0.81 [95% CI 0.70-0.93, p = 0.004]) in TZD users compared with non-TZD users in people with diabetes. A significant protective effect of TZD was observed in Caucasian population (3 studies) (HR 0.78 (95% CI 0.66-0.92), p = 0.003).
Conclusion: This meta-analysis demonstrates a potential neuroprotective effect of TZD for PD risk in the population with DM.
|Item Type:||Refereed Article|
|Keywords:||diabetes mellitus, glitazone, Parkinson's disease, pioglitazone, thiazolidinedione's, meta-analysis|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Neurology and neuromuscular diseases|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Singh, A (Mr Ambrish Singh)|
|UTAS Author:||Taylor, B (Professor Bruce Taylor)|
|UTAS Author:||Burgess, J (Professor John Burgess)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
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