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Thiazolidinedione use is associated with reduced risk of Parkinson's disease in patients with diabetes: a meta-analysis of real-world evidence
Citation
Hussain, S and Singh, A and Baxi, H and Taylor, B and Burgess, J and Antony, B, Thiazolidinedione use is associated with reduced risk of Parkinson's disease in patients with diabetes: a meta-analysis of real-world evidence, Neurological Sciences pp. 1-7. ISSN 1590-1874 (2020) [Refereed Article]
Copyright Statement
Copyright 2020 Fondazione Società Italiana di Neurologia
DOI: doi:10.1007/s10072-020-04494-3
Abstract
Method: A literature search was performed in PubMed, Embase, and Cochrane central from inception to until 30 September 2019. We included all real-world evidence studies assessing the use of TZD class of drugs and the risk of PD in people with diabetes. Quality of the studies was evaluated using the Newcastle-Ottawa scale. The primary outcome was the pooled hazard ratio (HR) of PD among type 2 DM TZD users as compared with TZD non-users in people with diabetes. The secondary outcome was the HR of PD among type 2 DM TZD users as compared with non-users (include both diabetic and nondiabetic population). Meta-analysis was performed using RevMan software.
Results: Out of five studies selected for inclusion, four studies fulfilled the criteria for primary outcomes. The participants' mean age and follow-up duration were 66.23 ± 9.59 years and 5.25 years (2.97-7.9 years), respectively. There was a significant reduction in the risk of PD (pooled adjusted HR of 0.81 [95% CI 0.70-0.93, p = 0.004]) in TZD users compared with non-TZD users in people with diabetes. A significant protective effect of TZD was observed in Caucasian population (3 studies) (HR 0.78 (95% CI 0.66-0.92), p = 0.003).
Conclusion: This meta-analysis demonstrates a potential neuroprotective effect of TZD for PD risk in the population with DM.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | diabetes mellitus, glitazone, Parkinson's disease, pioglitazone, thiazolidinedione's, meta-analysis |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurology and neuromuscular diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Singh, A (Mr Ambrish Singh) |
| UTAS Author: | Taylor, B (Professor Bruce Taylor) |
| UTAS Author: | Burgess, J (Professor John Burgess) |
| UTAS Author: | Antony, B (Dr Benny Eathakkattu Antony) |
| ID Code: | 139917 |
| Year Published: | 2020 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2020-07-15 |
| Last Modified: | 2020-08-17 |
| Downloads: | 0 |
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