Juonala, M and Wu, F and Sinaiko, A and Woo, JG and Urbina, EM and Jacobs, D and Steinberger, J and Prineas, R and Koskinen, J and Sabin, MA and Burgner, DP and Burns, TL and Bazzano, L and Venn, A and Viikari, JSA and Hutri-Kahonen, N and Daniels, SR and Dwyer, T and Raitakari, OT and Magnussen, CG, Non-HDL cholesterol levels in childhood and carotid intima-media thickness in adulthood, Pediatrics, 145, (4) Article e20192114. ISSN 0031-4005 (2020) [Refereed Article]
Copyright © 2020 by the American Academy of Pediatrics
Methods: We analyzed data from 4 prospective cohorts among 4582 children aged 3 to 19 years who were remeasured as adults (mean follow-up of 26 years). Non-HDL-C status in youth and adulthood was classified according to cut points of the National Heart, Lung, and Blood Institute and the National Cholesterol Education Program Adult Treatment Panel III. High carotid intima-media thickness (cIMT) in adulthood was defined as at or above the study visit-, age-, sex-, race-, and cohort-specific 90th percentile of intima-media thickness.
Results: In a log-binomial regression analysis adjusted with age at baseline, sex, cohort, length of follow-up, baseline BMI, and systolic blood pressure, children with dyslipidemic non-HDL-C were at increased risk of high cIMT in adulthood (relative risk [RR], 1.29; 95% confidence interval [CI], 1.07-1.55). Compared with the persistent normal group, the persistent dyslipidemia group (RR, 1.80; 95% CI, 1.37-2.37) and incident dyslipidemia (normal to dyslipidemia) groups (RR, 1.45; 95% CI, 1.07-1.96) had increased risk of high cIMT in adulthood, but the risk was attenuated for the resolution (dyslipidemia to normal) group (RR, 1.17; 95% CI, 0.97-1.41).
Conclusions: Dyslipidemic non-HDL-C levels predict youth at risk for developing high cIMT in adulthood. Those who resolve their non-HDL-C dyslipidemia by adulthood have normalized risk of developing high cIMT in adulthood.
|Item Type:||Refereed Article|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Wu, F (Dr Feitong Wu)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Magnussen, CG (Associate Professor Costan Magnussen)|
|Web of Science® Times Cited:||12|
|Deposited By:||Menzies Institute for Medical Research|
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