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Non-HDL cholesterol levels in childhood and carotid intima-media thickness in adulthood

Citation

Juonala, M and Wu, F and Sinaiko, A and Woo, JG and Urbina, EM and Jacobs, D and Steinberger, J and Prineas, R and Koskinen, J and Sabin, MA and Burgner, DP and Burns, TL and Bazzano, L and Venn, A and Viikari, JSA and Hutri-Kahonen, N and Daniels, SR and Dwyer, T and Raitakari, OT and Magnussen, CG, Non-HDL cholesterol levels in childhood and carotid intima-media thickness in adulthood, Pediatrics, 145, (4) Article e20192114. ISSN 0031-4005 (2020) [Refereed Article]


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DOI: doi:10.1542/peds.2019-2114

Abstract

Background: Elevated non-high-density lipoprotein cholesterol (HDL-C) levels are used to identify children at increased cardiovascular risk, but the use of non-HDL-C in childhood to predict atherosclerosis is unclear. We examined whether the National Heart, Lung, and Blood Institute classification of youth non-HDL-C status predicts high common carotid artery intima-media thickness in adulthood.

Methods: We analyzed data from 4 prospective cohorts among 4582 children aged 3 to 19 years who were remeasured as adults (mean follow-up of 26 years). Non-HDL-C status in youth and adulthood was classified according to cut points of the National Heart, Lung, and Blood Institute and the National Cholesterol Education Program Adult Treatment Panel III. High carotid intima-media thickness (cIMT) in adulthood was defined as at or above the study visit-, age-, sex-, race-, and cohort-specific 90th percentile of intima-media thickness.

Results: In a log-binomial regression analysis adjusted with age at baseline, sex, cohort, length of follow-up, baseline BMI, and systolic blood pressure, children with dyslipidemic non-HDL-C were at increased risk of high cIMT in adulthood (relative risk [RR], 1.29; 95% confidence interval [CI], 1.07-1.55). Compared with the persistent normal group, the persistent dyslipidemia group (RR, 1.80; 95% CI, 1.37-2.37) and incident dyslipidemia (normal to dyslipidemia) groups (RR, 1.45; 95% CI, 1.07-1.96) had increased risk of high cIMT in adulthood, but the risk was attenuated for the resolution (dyslipidemia to normal) group (RR, 1.17; 95% CI, 0.97-1.41).

Conclusions: Dyslipidemic non-HDL-C levels predict youth at risk for developing high cIMT in adulthood. Those who resolve their non-HDL-C dyslipidemia by adulthood have normalized risk of developing high cIMT in adulthood.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Magnussen, CG (Dr Costan Magnussen)
ID Code:139676
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-06-25
Last Modified:2020-06-25
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