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Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review
Erdrich, S and Hawrelak, JA and Myers, SP and Harnett, JE, Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review, BMC Musculoskeletal Disorders, 21, (1) Article 181. ISSN 1471-2474 (2020) [Refereed Article]
Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Background: The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia.
Methods: A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken.
Results: From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papers reporting Helicobacter pylori; other gut bacterial markers; metabolomics and other biomarkers, which included intestinal permeability and small intestinal bacterial overgrowth.
Conclusion: The results suggest there is a paucity of quality research in this area, with indications that the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.
|Item Type:||Refereed Article|
|Keywords:||fibromyalgia, fibromyalgia syndrome, gastrointestinal microbiome, biomarkers, systematic review|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Gastroenterology and hepatology|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Hawrelak, JA (Dr Jason Hawrelak)|
|Web of Science® Times Cited:||25|
|Downloads:||16 View Download Statistics|
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