Zhang, Y and Taylor, BV and Simpson Jr, S and Blizzard, L and Palmer, AJ and van der Mei, I, Validation of 0-10 MS symptom scores in the Australian multiple sclerosis longitudinal study, Multiple Sclerosis and Related Disorders, 39 Article 101895. ISSN 2211-0348 (2020) [Refereed Article]
© 2019 Elsevier B.V. All rights reserved.
Methods: The study included 1,985 participants from the Australian Multiple Sclerosis Longitudinal Study. Thirteen MS symptoms were assessed using the MSSymS, of which we were able to validate six (walking difficulties, fatigue, pain, feelings of anxiety, feelings of depression and vision problems). Comparison measures included Patient Determined Disease Steps (PDDS), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), and Assessment of Quality of Life (AQoL). We used spearman rank correlation for concurrent validity, linear regression for predictive validity, intra-class correlations for stability, and percentage change for responsiveness.
Results: We found high correlations between walking difficulties and PDDS (r = 0.82), pain and AQoL-pain (r = 0.77), fatigue and FSS (r = 0.72); moderate correlations between feelings of anxiety and HADS-Anxiety (r = 0.68), feelings of depression and HADS-Depression (r = 0.63); and low correlation between vision and AQoL-vision (r = 0.43) For predictive validity, the graphs with quality of life were largely overlapping and the R2 of the regression lines were generally similar. The stability and responsiveness of the MSSymS were adequate.
Conclusion: The six assessed symptoms of the MSSymS performed equally well compared to validated comparison measures in terms of concurrent and predictive validity, temporal stability and responsiveness.
|Item Type:||Refereed Article|
|Keywords:||multiple sclerosis, symptom measure, numeric rating scale, validity, responsiveness, MSSymS|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Central nervous system|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Zhang, Y (Miss Yan Zhang)|
|UTAS Author:||Taylor, BV (Professor Bruce Taylor)|
|UTAS Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|UTAS Author:||Blizzard, L (Professor Leigh Blizzard)|
|UTAS Author:||Palmer, AJ (Professor Andrew Palmer)|
|UTAS Author:||van der Mei, I (Professor Ingrid van der Mei)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
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