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Baseline white matter is associated with physical fitness change in preclinical Alzheimer's disease


Venkatraman, VK and Steward, CE and Cox, KL and Ellis, KA and Phal, PM and Sharman, MJ and Villemagne, VL and Lai, MMY and Cyarto, EV and Ames, D and Szoeke, C and Rowe, CC and Masters, CL and Lautenschlager, NT and Desmond, PM, Baseline white matter is associated with physical fitness change in preclinical Alzheimer's disease, Frontiers in Aging Neuroscience, 12 pp. 1-12. ISSN 1663-4365 (2020) [Refereed Article]


Copyright Statement

Copyright 2020 Venkatraman, Steward, Cox, Ellis, Phal, Sharman, Villemagne, Lai, Cyarto, Ames, Szoeke, Rowe, Masters, Lautenschlager and Desmond. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fnagi.2020.00115


White matter (WM) microstructure is a sensitive marker to distinguish individuals at risk of Alzheimer's disease. The association of objective physical fitness (PF) measures and WM microstructure has not been explored and mixed results reported with physical activity (PA). Longitudinal studies of WM with PA and PF measures have had limited investigation. This study explored the relationship between objective PF measures over 24-months with "normal-appearing" WM microstructure. Data acquired on magnetic resonance imaging was used to measure "normal-appearing" WM microstructure at baseline and 24-months. Clinical variables such as cognitive and blood-based measures were collected longitudinally. Also, as part of the randomized controlled trial of a PA, extensive measures of PA and fitness were obtained over the 24 months. Bilateral corticospinal tracts (CST) and the corpus callosum showed a significant association between PF performance over 24-months and baseline WM microstructural measures. There was no significant longitudinal effect of the intervention or PF performance over 24-months. Baseline WM microstructural measures were significantly associated with PF performance over 24-months in this cohort of participants with vascular risk factors and at risk of Alzheimer's disease with distinctive patterns for each PF test.

Item Details

Item Type:Refereed Article
Keywords:MCI (mild cognitive impairment), MRI, DWI, objective physical fitness measures, physical activity intervention
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, MJ (Dr Matt Sharman)
ID Code:139472
Year Published:2020
Web of Science® Times Cited:5
Deposited By:Health Sciences
Deposited On:2020-06-17
Last Modified:2022-08-23
Downloads:14 View Download Statistics

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