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Effect of aspirin vs placebo on the prevention of depression in older people: a randomized clinical trial


Berk, M and Woods, RL and Nelson, MR and Shah, RC and Reid, CM and Storey, E and Fitzgerald, S and Lockery, JE and Wolfe, R and Mohebbi, M and Dodd, S and Murray, AM and Stocks, N and Fitzgerald, PB and Mazza, C and Agustini, B and McNeil, JJ, Effect of aspirin vs placebo on the prevention of depression in older people: a randomized clinical trial, JAMA Psychiatry, 77, (10) pp. 1012-1020. ISSN 2168-622X (2020) [Refereed Article]


Copyright Statement

2020 American Medical Association. All rights reserved.

DOI: doi:10.1001/jamapsychiatry.2020.1214


Importance: Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There currently appears to be no evidence-based pharmacotherapies for the primary prevention of depression.

Objective: To determine whether low-dose aspirin (100 mg) reduces the risk of depression in healthy older adults.

Design, setting, and participants: This double-blinded, placebo-controlled randomized clinical trial was a substudy of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, which examined if aspirin increased healthy life span, defined as survival free of dementia and disability. The prespecified secondary outcome was depression. Individuals of all races/ethnicities older than 70 years in Australia, as well as white individuals older than 70 years and black and Hispanic individuals older than 65 years in the United States, were included.

Interventions: Participants were randomized to aspirin (100 mg daily) or placebo, with a median (interquartile range) follow-up of 4.7 (3.5-5.6) years.

Main outcomes and measures: The primary outcome was a proxy measure of major depressive disorder defined as a score of 8 or more on the Center for Epidemiologic Studies Depression 10-item (CES-D-10) scale.

Results: Of the 19 114 participants enrolled in the trial, 9525 received aspirin and 9589 received a placebo. The mean (SD) age was 75.2 (4.0) years in the aspirin group and 75.1 (4.5) years in the placebo group; 9531 (56.4%) were women. Participants' demographics and clinical characteristics at baseline were similar between groups. A total of 79 886 annual CES-D-10 measurements were taken, with a mean of 4.2 measurements per participant. There were no significant differences at annual visits in the proportions of CES-D-10 scores of 8 or more between the aspirin and placebo groups. The incidence rate of new CES-D-10 scores of 8 or more was 70.4 events per 1000 person-years in the aspirin group and 69.1 in the placebo group (hazard ratio, 1.02 [95% CI, 0.96-1.08]; P = .54).

Conclusions and relevance: Low-dose aspirin did not prevent depression in this large-scale study of otherwise healthy older adults.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Nelson, MR (Professor Mark Nelson)
ID Code:139275
Year Published:2020
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-06-04
Last Modified:2021-03-24
Downloads:13 View Download Statistics

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