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Patterns of association between depressive symptoms and chronic medical morbidities in older adults
Citation
Agustini, B and Lotfaliany, M and Woods, RL and McNeil, JJ and Nelson, MR and Shah, RC and Murray, AM and Ernst, ME and Reid, CM and Tonkin, A and Lockery, JE and Williams, LJ and Berk, M and Mohebbi, M, ASPREE Investigator Group, Patterns of association between depressive symptoms and chronic medical morbidities in older adults, Journal of the American Geriatrics Society, 68, (8) pp. 1834-1841. ISSN 0002-8614 (2020) [Refereed Article]
Copyright Statement
© 2020 The American Geriatrics Society
Abstract
Setting: Multicentric study conducted in Australia and the United States.
Participants: A total of 19,110 older adults (mean age = 75 years [standard deviation = ±4.5]).
Measurements: Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders.
Results: Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07-1.32), diabetes (OR = 1.22; 95% CI = 1.05-1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28-1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03-1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27-1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10-1.42), history of cancer (OR = 1.19; 95% CI = 1.05-1.34), Parkinson's disease (OR = 2.56; 95% CI = 1.83-3.56), polypharmacy (OR = 1.60; 95% CI = 1.44-1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12-1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P > .05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13-1.22).
Conclusion: Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals.
Item Details
Item Type: | Refereed Article |
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Keywords: | depression, late-life depression, medical comorbidity, polypharmacy, somatic conditions |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Geriatrics and gerontology |
Objective Division: | Health |
Objective Group: | Specific population health (excl. Indigenous health) |
Objective Field: | Health related to ageing |
UTAS Author: | Nelson, MR (Professor Mark Nelson) |
ID Code: | 139273 |
Year Published: | 2020 |
Web of Science® Times Cited: | 21 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2020-06-04 |
Last Modified: | 2021-04-26 |
Downloads: | 0 |
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