Agustini, B and Lotfaliany, M and Woods, RL and McNeil, JJ and Nelson, MR and Shah, RC and Murray, AM and Ernst, ME and Reid, CM and Tonkin, A and Lockery, JE and Williams, LJ and Berk, M and Mohebbi, M, ASPREE Investigator Group, Patterns of association between depressive symptoms and chronic medical morbidities in older adults, Journal of the American Geriatrics Society, 68, (8) pp. 1834-1841. ISSN 0002-8614 (2020) [Refereed Article]
© 2020 The American Geriatrics Society
Setting: Multicentric study conducted in Australia and the United States.
Participants: A total of 19,110 older adults (mean age = 75 years [standard deviation = ±4.5]).
Measurements: Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders.
Results: Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07-1.32), diabetes (OR = 1.22; 95% CI = 1.05-1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28-1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03-1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27-1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10-1.42), history of cancer (OR = 1.19; 95% CI = 1.05-1.34), Parkinson's disease (OR = 2.56; 95% CI = 1.83-3.56), polypharmacy (OR = 1.60; 95% CI = 1.44-1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12-1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P > .05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13-1.22).
Conclusion: Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals.
|Item Type:||Refereed Article|
|Keywords:||depression, late-life depression, medical comorbidity, polypharmacy, somatic conditions|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Geriatrics and gerontology|
|Objective Group:||Specific population health (excl. Indigenous health)|
|Objective Field:||Health related to ageing|
|UTAS Author:||Nelson, MR (Professor Mark Nelson)|
|Web of Science® Times Cited:||15|
|Deposited By:||Menzies Institute for Medical Research|
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